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Effects of Low-Dose X-ray Irradiation on Melanin-Derived Radicals in Mouse Hair and Skin
https://repo.qst.go.jp/records/79594
https://repo.qst.go.jp/records/79594eec051c3-89a7-498b-b873-5c8a9319dc6b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Matsumoto.K.2020.J.Clin.Biochem.Nutr.67.174-178.MelaninRadical.pdf (457.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-03-03 | |||||
| タイトル | ||||||
| タイトル | Effects of Low-Dose X-ray Irradiation on Melanin-Derived Radicals in Mouse Hair and Skin | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ken-ichiro, Matsumoto
× Ken-ichiro, Matsumoto× Ueno, Megumi× Nakanishi, Ikuo× P. Indou, Hiroko× J. Majima, Hideyuki× Kenichiro, Matsumoto× Megumi, Ueno× Ikuo, Nakanishi× Hiroko, Indou× Hideyuki, Majima |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To find the possible index for long term and low dose irradiation, the effect of repeated low dose X-ray irradiation on the melanin-derived radicals in mouse hair and tail skin was investigated. Female 8-week-old C3H/HeSlc mice were irradiated by X-ray with dose of 100 mGy/day on 5 days/week (Mon to Fri) for 12 weeks. Similarly, 4-week irradiation experiment was carried out with 500 mGy/day for C3H/HeSlc mice, or with 10, 100, and 500 mGy/day for female 8-week-old C57BL/6NCrSlc mice. An aliquot (~10 mg) of the hair sample was weighed accurately and stuffed in a plastic tube. The 2 cm tip of the tail was sampled and lyophilized. Melanin-derived radicals in hair and tail samples were measured by X-band (9.4 GHz) electron paramagnetic resonance (EPR) spectrometer. Effect of 1 mM 4-hydroxyl-2,2,6,6-tetramethylpiperidine-N-oxyl (TPL) added in drinking water on the melanin-derived radicals in hair and tail sample was tested. After the X-ray irradiation at 100 mGy/day for 12 weeks, no difference was obtained for melanin-derived radicals in the hair of the irradiated and non-irradiated groups. The X-ray irradiation at 500 mGy/day for 4 weeks makes melanin-derived radicals increased in hair compared to non-irradiated group. Melanin-derived radicals in hair may be responsible for X-ray irradiation but the threshold dose was expected; the amount of melanin-derived radicals in the tail skin was increased as dose dependently. The melanin-derived radicals in skin may be an endogenous marker for long term and low dose irradiation. | |||||
| 書誌情報 |
Journal of Clinical Biochemistry and Nutrition 巻 67, 号 2, p. 174-178, 発行日 2020-06 |
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| 出版者 | ||||||
| 出版者 | 日本酸化ストレス学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0912-0009 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3164/jcbn.20-34 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.3164/jcbn.20-34 | |||||
