{"created":"2023-05-15T14:58:40.113813+00:00","id":79594,"links":{},"metadata":{"_buckets":{"deposit":"2c2cc68f-bb05-43de-9acc-8c15e08fddc6"},"_deposit":{"created_by":1,"id":"79594","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"79594"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00079594","sets":["1"]},"author_link":["1014219","1014220","1014221","1014225","1014218","1014222","1014224","1014223","1014226","1014217"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"178","bibliographicPageStart":"174","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Biochemistry and Nutrition"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To find the possible index for long term and low dose irradiation, the effect of repeated low dose X-ray irradiation on the melanin-derived radicals in mouse hair and tail skin was investigated. Female 8-week-old C3H/HeSlc mice were irradiated by X-ray with dose of 100 mGy/day on 5 days/week (Mon to Fri) for 12 weeks. Similarly, 4-week irradiation experiment was carried out with 500 mGy/day for C3H/HeSlc mice, or with 10, 100, and 500 mGy/day for female 8-week-old C57BL/6NCrSlc mice. An aliquot (~10 mg) of the hair sample was weighed accurately and stuffed in a plastic tube. The 2 cm tip of the tail was sampled and lyophilized. Melanin-derived radicals in hair and tail samples were measured by X-band (9.4 GHz) electron paramagnetic resonance (EPR) spectrometer. Effect of 1 mM 4-hydroxyl-2,2,6,6-tetramethylpiperidine-N-oxyl (TPL) added in drinking water on the melanin-derived radicals in hair and tail sample was tested. After the X-ray irradiation at 100 mGy/day for 12 weeks, no difference was obtained for melanin-derived radicals in the hair of the irradiated and non-irradiated groups. The X-ray irradiation at 500 mGy/day for 4 weeks makes melanin-derived radicals increased in hair compared to non-irradiated group. Melanin-derived radicals in hair may be responsible for X-ray irradiation but the threshold dose was expected; the amount of melanin-derived radicals in the tail skin was increased as dose dependently. The melanin-derived radicals in skin may be an endogenous marker for long term and low dose irradiation.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本酸化ストレス学会"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3164/jcbn.20-34","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3164/jcbn.20-34","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-0009","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ken-ichiro, Matsumoto"}],"nameIdentifiers":[{"nameIdentifier":"1014217","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ueno, Megumi"}],"nameIdentifiers":[{"nameIdentifier":"1014218","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakanishi, Ikuo"}],"nameIdentifiers":[{"nameIdentifier":"1014219","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"P. Indou, Hiroko"}],"nameIdentifiers":[{"nameIdentifier":"1014220","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"J. Majima, Hideyuki"}],"nameIdentifiers":[{"nameIdentifier":"1014221","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kenichiro, Matsumoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014222","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Megumi, Ueno","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014223","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikuo, Nakanishi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014224","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroko, Indou","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014225","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hideyuki, Majima","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014226","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-28"}],"displaytype":"detail","filename":"c5f20e3b6fb927661b10b11ef178ca79.pdf","filesize":[{"value":"457.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Matsumoto.K.2020.J.Clin.Biochem.Nutr.67.174-178.MelaninRadical.pdf","url":"https://repo.qst.go.jp/record/79594/files/c5f20e3b6fb927661b10b11ef178ca79.pdf"},"version_id":"4e9f2b53-9591-4fe9-a6da-c828bacb5607"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Low-Dose X-ray Irradiation on Melanin-Derived Radicals in Mouse Hair and Skin","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Low-Dose X-ray Irradiation on Melanin-Derived Radicals in Mouse Hair and Skin"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-03"},"publish_date":"2020-03-03","publish_status":"0","recid":"79594","relation_version_is_last":true,"title":["Effects of Low-Dose X-ray Irradiation on Melanin-Derived Radicals in Mouse Hair and Skin"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:49:26.079252+00:00"}