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Carbon-Ion Beam Irradiation Alone or in Combination with Zoledronic Acid Effectively Kills Osteosarcoma Cells.
https://repo.qst.go.jp/records/79563
https://repo.qst.go.jp/records/79563e8a34907-4b4a-4d0a-b611-a20c0995c687
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-03-18 | |||||
| タイトル | ||||||
| タイトル | Carbon-Ion Beam Irradiation Alone or in Combination with Zoledronic Acid Effectively Kills Osteosarcoma Cells. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ho Kim, Eun
× Ho Kim, Eun× Mi-Sook, Kim× Takahashi, Akihisa× Suzuki, Masao× Vares, Guillaume× Uzawa, Akiko× Fujimori, Akira× Ohno, Tatsuya× Sai, Sei× Ho Kim, Eun× Akihisa, Takahashi× Masao, Suzuki× Vares, Guillaume× Akiko, Uzawa× Akira, Fujimori× Tatsuya, Ohno× Sei, Sai |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Osteosarcoma (OSA) is the most common malignant bone tumor in children and adolescents. The overall five-year survival rate for all bone cancers is below 70%; however, when the cancer has spread beyond the bone, it is about 15–30%. Herein, we evaluated the effects of carbon-ion beam irradiation alone or in combination with zoledronic acid (ZOL) on OSA cells. Carbon-ion beam irradiation in combination with ZOL significantly inhibited OSA cell proliferation by arresting cell cycle progression and initiating KHOS and U2OS cell apoptosis, compared to treatments with carbon-ion beam irradiation, X-ray irradiation, and ZOL alone. Moreover, we observed that this combination greatly inhibited OSA cell motility and invasion, accompanied by the suppression of the Pi3K/Akt and MAPK signaling pathways, which are related to cell proliferation and survival, compared to individual treatments with carbon-ion beam or X-ray irradiation, or ZOL. Furthermore, ZOL treatment upregulated microRNA (miR)-29b expression; the combination with a miR-29b mimic further decreased OSA cell viability via activation of the caspase 3 pathway. Thus, ZOL-mediated enhancement of carbon-ion beam radiosensitivity may occur via miR-29b upregulation; co-treatment with the miR-29b mimic further decreased OSA cell survival. These findings suggest that the carbon-ion beam irradiation in combination with ZOL has high potential to increase OSA cell death. | |||||
| 書誌情報 |
Cancers 巻 12, 号 3, p. 698, 発行日 2020-03 |
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| 出版者 | ||||||
| 出版者 | MDPI | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2072-669 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/cancers12030698 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/2072-6694/12/3/698 | |||||
