{"created":"2023-05-15T14:58:38.719304+00:00","id":79563,"links":{},"metadata":{"_buckets":{"deposit":"4c91636a-0abc-4fb0-8029-81e25aec280d"},"_deposit":{"created_by":1,"id":"79563","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"79563"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00079563","sets":["1"]},"author_link":["1007610","1007622","1007613","1007615","1007618","1007617","1007619","1007612","1007620","1007609","1007621","1007614","1007623","1007616","1007611","1007608","1007607"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageStart":"698","bibliographicVolumeNumber":"12 ","bibliographic_titles":[{"bibliographic_title":"Cancers"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Osteosarcoma (OSA) is the most common malignant bone tumor in children and adolescents. The overall five-year survival rate for all bone cancers is below 70%; however, when the cancer has spread beyond the bone, it is about 15–30%. Herein, we evaluated the effects of carbon-ion beam irradiation alone or in combination with zoledronic acid (ZOL) on OSA cells. Carbon-ion beam irradiation in combination with ZOL significantly inhibited OSA cell proliferation by arresting cell cycle progression and initiating KHOS and U2OS cell apoptosis, compared to treatments with carbon-ion beam irradiation, X-ray irradiation, and ZOL alone. Moreover, we observed that this combination greatly inhibited OSA cell motility and invasion, accompanied by the suppression of the Pi3K/Akt and MAPK signaling pathways, which are related to cell proliferation and survival, compared to individual treatments with carbon-ion beam or X-ray irradiation, or ZOL. Furthermore, ZOL treatment upregulated microRNA (miR)-29b expression; the combination with a miR-29b mimic further decreased OSA cell viability via activation of the caspase 3 pathway. Thus, ZOL-mediated enhancement of carbon-ion beam radiosensitivity may occur via miR-29b upregulation; co-treatment with the miR-29b mimic further decreased OSA cell survival. These findings suggest that the carbon-ion beam irradiation in combination with ZOL has high potential to increase OSA cell death.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/cancers12030698","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/2072-6694/12/3/698","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2072-669","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ho Kim, Eun"}],"nameIdentifiers":[{"nameIdentifier":"1007607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mi-Sook, Kim"}],"nameIdentifiers":[{"nameIdentifier":"1007608","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Akihisa"}],"nameIdentifiers":[{"nameIdentifier":"1007609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Masao"}],"nameIdentifiers":[{"nameIdentifier":"1007610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Vares, Guillaume"}],"nameIdentifiers":[{"nameIdentifier":"1007611","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uzawa, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"1007612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujimori, Akira"}],"nameIdentifiers":[{"nameIdentifier":"1007613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohno, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"1007614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sai, Sei"}],"nameIdentifiers":[{"nameIdentifier":"1007615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ho Kim, Eun","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akihisa, Takahashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masao, Suzuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Vares, Guillaume","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007619","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akiko, Uzawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007620","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akira, Fujimori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007621","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tatsuya, Ohno","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007622","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sei, Sai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1007623","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Carbon-Ion Beam Irradiation Alone or in Combination with Zoledronic Acid Effectively Kills Osteosarcoma Cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carbon-Ion Beam Irradiation Alone or in Combination with Zoledronic Acid Effectively Kills Osteosarcoma Cells."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-18"},"publish_date":"2020-03-18","publish_status":"0","recid":"79563","relation_version_is_last":true,"title":["Carbon-Ion Beam Irradiation Alone or in Combination with Zoledronic Acid Effectively Kills Osteosarcoma Cells."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:15:24.674664+00:00"}