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Evaluation of ionizing radiation induced DNA damage on a cell by integrated Monte Carlo simulations using Geant4-DNA
https://repo.qst.go.jp/records/79467
https://repo.qst.go.jp/records/79467245e8195-807a-41fc-904b-2f50ffc1775a
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-03-16 | |||||
| タイトル | ||||||
| タイトル | Evaluation of ionizing radiation induced DNA damage on a cell by integrated Monte Carlo simulations using Geant4-DNA | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
坂田, 洞察
× 坂田, 洞察× Sakata, Dousatsu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Monte Carlo (MC) mechanistic simulations are a promising tool for the modeling of early DNA damage induction by ionizing radiation. They indeed provide functionalities which allow simulations not only for physical interactions but also for chemical processes in combination with simplified geometries of biological targets to predict such ionizing radiation induced DNA damage. In the last decades, several MC codes were developed to predict DNA damage, like KURBUC, PARTRAC and Geant4-DNA. Recently, Geant4-DNA has demonstrated the possibility to evaluate early DNA damage in an E. coli bacterium and in a fibroblast cell nucleus [8] irradiated by protons. In this presentation, as a milestone of the 10 years developments, we describe for the first time the combination of such features (physics, chemistry and biological geometry) in a single Geant4-DNA application for the modelling of early DNA damage induction in a cell, irradiated with protons in the incident energy range (0.1 – 50 MeV). Results are compared to the experimental data and the past simulations which are available in the literatures. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 基研研究会 放射線の生体影響解明への分野横断による挑戦 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-05-25 | |||||
| 日付タイプ | Issued | |||||
