@misc{oai:repo.qst.go.jp:00079467,
 author = {坂田, 洞察 and Sakata, Dousatsu},
 month = {May},
 note = {Monte Carlo (MC) mechanistic simulations are a promising tool for the modeling of early DNA damage induction by ionizing radiation. They indeed provide functionalities which allow simulations not only for physical interactions but also for chemical processes in combination with simplified geometries of biological targets to predict such ionizing radiation induced DNA damage. In the last decades, several MC codes were developed to predict DNA damage, like KURBUC, PARTRAC  and Geant4-DNA. Recently, Geant4-DNA has demonstrated the possibility to evaluate early DNA damage in an E. coli bacterium and in a fibroblast cell nucleus [8] irradiated by protons. In this presentation, as a milestone of the 10 years developments, we describe for the first time the combination of such features (physics, chemistry and biological geometry) in a single Geant4-DNA application for the modelling of early DNA damage induction in a cell, irradiated with protons in the incident energy range (0.1 – 50 MeV). Results are compared to the experimental data and the past simulations which are available in the literatures., 基研研究会 放射線の生体影響解明への分野横断による挑戦},
 title = {Evaluation of ionizing radiation induced DNA damage on a cell by integrated Monte Carlo simulations using Geant4-DNA},
 year = {2019}
}