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6-[124I]Iodo-9-pentylpurine for Imaging the Activity of the Sodium Iodide Symporter in the Brain
https://repo.qst.go.jp/records/79414
https://repo.qst.go.jp/records/79414eb9e4cef-f11a-4601-b029-14cc7c545fbb
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-03-13 | |||||
| タイトル | ||||||
| タイトル | 6-[124I]Iodo-9-pentylpurine for Imaging the Activity of the Sodium Iodide Symporter in the Brain | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okamura, Toshimitsu
× Okamura, Toshimitsu× Tsukamoto, Satoshi× Nagatsu, Kotaro× Okada, Maki× Minegishi, Katsuyuki× Tatsumi, Takayuki× Sugyo, Aya× Kikuchi, Tatsuya× Wakizaka, Hidekatsu× Ishii, Hideki× Tsuji, Atsushi× Ming-Rong, Zhang× Toshimitsu, Okamura× Satoshi, Tsukamoto× Kotaro, Nagatsu× Maki, Okada× Katsuyuki, Minegishi× Aya, Sugyo× Tatsuya, Kikuchi× Hidekatsu, Wakizaka× Hideki, Ishii× Atsushi, Tsuji× Zhang, Ming-Rong |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Iodide homeostasis and thyroid hormone metabolism in the brain are potentially related to changes in the activity of the sodium iodide symporter (NIS). No radiotracers are currently available for imaging brain NIS activity. Here, we synthesized 6[124I]iodo-9-pentylpurine that can noninvasively measure iodide efflux from the brain and showed that the efflux rate of [124I]I− in NIS knockout mice was 84% lower than that of wild-type mice. Thus, 6-[124I]iodo-9-pentylpurine would be useful for imaging brain NIS activity. | |||||
| 書誌情報 |
Journal of Medicinal Chemistry 巻 63, 号 4, p. 1717-1723, 発行日 2020-02 |
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| 出版者 | ||||||
| 出版者 | ACS Publications | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0022-2623 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1021/acs.jmedchem.9b02096 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b02096 | |||||
