@article{oai:repo.qst.go.jp:00079414,
 author = {Okamura, Toshimitsu and Tsukamoto, Satoshi and Nagatsu, Kotaro and Okada, Maki and Minegishi, Katsuyuki and Tatsumi, Takayuki and Sugyo, Aya and Kikuchi, Tatsuya and Wakizaka, Hidekatsu and Ishii, Hideki and Tsuji, Atsushi and Ming-Rong, Zhang and Toshimitsu, Okamura and Satoshi, Tsukamoto and Kotaro, Nagatsu and Maki, Okada and Katsuyuki, Minegishi and Aya, Sugyo and Tatsuya, Kikuchi and Hidekatsu, Wakizaka and Hideki, Ishii and Atsushi, Tsuji and Zhang, Ming-Rong},
 issue = {4},
 journal = {Journal of Medicinal Chemistry},
 month = {Feb},
 note = {Iodide homeostasis and thyroid hormone metabolism in the brain are potentially related to changes in the activity of the sodium iodide symporter (NIS). No radiotracers are currently available for imaging brain NIS activity. Here, we synthesized 6[124I]iodo-9-pentylpurine that can noninvasively measure iodide efflux from the brain and showed that the efflux rate of [124I]I− in NIS knockout mice was 84% lower than that of wild-type mice. Thus, 6-[124I]iodo-9-pentylpurine would be useful for imaging brain NIS activity.},
 pages = {1717--1723},
 title = {6-[124I]Iodo-9-pentylpurine for Imaging the Activity of the Sodium Iodide Symporter in the Brain},
 volume = {63},
 year = {2020}
}