ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 原著論文

Minimally invasive manganese-enhanced magnetic resonance imaging for the sciatic nerve tract tracing used intra-articularly administrated dextran-manganese encapsulated nanogels.

https://repo.qst.go.jp/records/79160
https://repo.qst.go.jp/records/79160
79b9c2f6-b719-4ea5-bc60-452e09a31bc7
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-03-03
タイトル
タイトル Minimally invasive manganese-enhanced magnetic resonance imaging for the sciatic nerve tract tracing used intra-articularly administrated dextran-manganese encapsulated nanogels.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Eguchi, Yawara

× Eguchi, Yawara

WEKO 999513

Eguchi, Yawara

Search repository
Murayama, Shuhei

× Murayama, Shuhei

WEKO 999514

Murayama, Shuhei

Search repository
Kanamoto, Hirohito

× Kanamoto, Hirohito

WEKO 999515

Kanamoto, Hirohito

Search repository
Abe, Koki

× Abe, Koki

WEKO 999516

Abe, Koki

Search repository
Miyagi, Masayuki

× Miyagi, Masayuki

WEKO 999517

Miyagi, Masayuki

Search repository
Takahashi, Kazuhisa

× Takahashi, Kazuhisa

WEKO 999518

Takahashi, Kazuhisa

Search repository
Ohtori, Seiji

× Ohtori, Seiji

WEKO 999519

Ohtori, Seiji

Search repository
Aoki, Ichio

× Aoki, Ichio

WEKO 999520

Aoki, Ichio

Search repository
Yawara, Eguchi

× Yawara, Eguchi

WEKO 999521

en Yawara, Eguchi

Search repository
Ichio, Aoki

× Ichio, Aoki

WEKO 999522

en Ichio, Aoki

Search repository
抄録
内容記述タイプ Abstract
内容記述 Manganese-enhanced magnetic resonance imaging (MEMRI) enables tract tracing to follow neural pathways through axonal transport. However, the method is problematic because of the high local concentrations of Mn involved. We developed a tetrananogel containing a dextran-manganese complex (Dex-Mn-Gel) and applied this nanogel to rats. MnCl (n = 5), Dex-Mn-Gel (n = 5), or saline control (n = 3) was injected into the left knee joint of the rats (n = 13). Inflammation and tissue alterations in the knee joint were also evaluated histologically. T1-weighted images were obtained on a 7 T MRI system 24 hours after the administration and compared across groups. The sciatic nerve in both legs and the surrounding musculature were used as regions of interest (ROI). No swelling was found in the knee joint infused with Dex-Mn-Gel, although prominent swelling of the knee joint was observed with MnCl. White blood cells inside the knee joint tissue infused with the Dex-Mn-Gel were significantly less abundant (45%,  < .05) compared with the knee joints infused with MnCl. Visualization of the sciatic nerve was significantly enhanced in rats treated with both forms of Mn compared with controls ( < .01). This study is the first to attempt intra-articular administration of a manganese contrast agent into joint-capsule and demonstrate tract visualization. The Dex-Mn-Gel can be taken up by the nerve endings and reduce Mn toxicity. Dex-Mn-Gel will provide a minimally invasive method for visualizing nerve tracts in vivo.
書誌情報 JOR spine

巻 2, 号 2, p. e1059, 発行日 2019-06
出版者
出版者 Wiley
ISSN
収録物識別子タイプ ISSN
収録物識別子 2572-1143
PubMed番号
識別子タイプ PMID
関連識別子 31463469
DOI
識別子タイプ DOI
関連識別子 10.1002/jsp2.1059
関連サイト
識別子タイプ URI
関連識別子 https://onlinelibrary.wiley.com/doi/full/10.1002/jsp2.1059
戻る
0
views
See details
Views

Versions

Ver.1 2023-05-15 17:32:32.789716
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3