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Establishment of a simplified method to quantify [18F]PM-PBB3 ([18F]APN-1607) binding in the brains of living human subjects
https://repo.qst.go.jp/records/78239
https://repo.qst.go.jp/records/78239428e5e8f-e484-498b-b994-35f2b4906324
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-12-25 | |||||
| タイトル | ||||||
| タイトル | Establishment of a simplified method to quantify [18F]PM-PBB3 ([18F]APN-1607) binding in the brains of living human subjects | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Seki, Chie
× Seki, Chie× Tagai, Kenji× Shimada, Hitoshi× Kitamura, Soichiro× Kimura, Yasuyuki× Ichise, Masanori× Ono, Maiko× Takahata, Keisuke× Kubota, Manabu× Takado, Yuhei× Okada, Maki× Kikuchi, Tatsuya× Ming-Rong, Zhang× Suhara, Tetsuya× Higuchi, Makoto× Seki, Chie× Tagai, Kenji× Shimada, Hitoshi× Kitamura, Soichiro× Kimura, Yasuyuki× Ichise, Masanori× Ono, Maiko× Takahata, Keisuke× Kubota, Manabu× Takado, Yuhei× Okada, Maki× Kikuchi, Tatsuya× Ming-Rong, Zhang× Suhara, Tetsuya× Higuchi, Makoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aim PET imaging with [18F]PM-PBB3 ([18F]APN-1607) has demonstrated the capability of this radioligand for high-contrast visualization of tau deposits in the brains of Alzheimer’s disease (AD) and diverse other neurodegenerative disorders. This study was aimed at determining an optimal time frame of a PET scan to obtain a reliable target-to-reference ratio of radioligand concentrations in comparison with analytical models with an arterial input function. Methods Ten subjects consisting of 5 healthy controls (HCs) and 3 AD and 2 progressive supranuclear palsy (PSP) patients underwent dynamic PET scans over 150 or 180 minutes after intravenous injection of [18F]PM-PBB3. Serial arterial blood samples were withdrawn during the scan to determine a metabolite-corrected plasma input function. Regional time-activity curves were analyzed with 1- and 2-tissue compartment models (TCMs) and Logan’s graphical analysis (LGA). Time-stability of total distribution (VT) values was examined to estimate scan duration sufficient for determination of VT. Non-displaceable biding potential (BPND) of [18F]PM-PBB3 was calculated using VT obtained with LGA, and SUVR in a 20-minute frame beginning at different time points after radioligand injection was calculated. SUVR-1 values were then compared with BPND to determine an optimal scan frame. Results A peak [18F]PM-PBB3 SUV in the brain approximated 2.5 at < 5 minutes, followed by rapid radioactivity washout. Radioligand retentions in the lateral temporal cortex of AD patients and midbrain of PSP patients were characteristically increased relative to HCs. Two-TCM better described the radioligand kinetics in target regions than 1-TCM. VT values obtained with LGA presented the highest time-stability, and SUVR-1 values at 90-110 min showed the highest correlation with BPND among different frames. Conclusions [18F]PM-PBB3 kinetics showed reversible binding and could be described without radiometabolite compartments in the brain. Estimation of SUVR at 90-110 min can be employed as a simplified means to quantify radioligand retention with sufficient robustness. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 13th Human Amyloid Imaging Conference | |||||
| 発表年月日 | ||||||
| 日付 | 2019-01-17 | |||||
| 日付タイプ | Issued | |||||
