{"created":"2023-05-15T14:57:38.888349+00:00","id":78239,"links":{},"metadata":{"_buckets":{"deposit":"017ca2ad-1ed4-420f-b9d6-a0014e58ce79"},"_deposit":{"created_by":1,"id":"78239","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"78239"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00078239","sets":["10:28"]},"author_link":["818245","818243","818234","818244","818235","818239","818251","818253","818238","818241","818242","818252","818249","818237","818259","818248","818261","818233","818260","818262","818258","818254","818257","818250","818247","818240","818236","818246","818255","818256"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-01-17","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim \nPET imaging with [18F]PM-PBB3 ([18F]APN-1607) has demonstrated the capability of this radioligand for high-contrast visualization of tau deposits in the brains of Alzheimer’s disease (AD) and diverse other neurodegenerative disorders. This study was aimed at determining an optimal time frame of a PET scan to obtain a reliable target-to-reference ratio of radioligand concentrations in comparison with analytical models with an arterial input function.\nMethods \nTen subjects consisting of 5 healthy controls (HCs) and 3 AD and 2 progressive supranuclear palsy (PSP) patients underwent dynamic PET scans over 150 or 180 minutes after intravenous injection of [18F]PM-PBB3. Serial arterial blood samples were withdrawn during the scan to determine a metabolite-corrected plasma input function. Regional time-activity curves were analyzed with 1- and 2-tissue compartment models (TCMs) and Logan’s graphical analysis (LGA). Time-stability of total distribution (VT) values was examined to estimate scan duration sufficient for determination of VT. Non-displaceable biding potential (BPND) of [18F]PM-PBB3 was calculated using VT obtained with LGA, and SUVR in a 20-minute frame beginning at different time points after radioligand injection was calculated. SUVR-1 values were then compared with BPND to determine an optimal scan frame.  \nResults\nA peak [18F]PM-PBB3 SUV in the brain approximated 2.5 at < 5 minutes, followed by rapid radioactivity washout. Radioligand retentions in the lateral temporal cortex of AD patients and midbrain of PSP patients were characteristically increased relative to HCs. Two-TCM better described the radioligand kinetics in target regions than 1-TCM. VT values obtained with LGA presented the highest time-stability, and SUVR-1 values at 90-110 min showed the highest correlation with BPND among different frames. \nConclusions\n[18F]PM-PBB3 kinetics showed reversible binding and could be described without radiometabolite compartments in the brain. Estimation of SUVR at 90-110 min can be employed as a simplified means to quantify radioligand retention with sufficient robustness. \n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"13th Human Amyloid Imaging Conference","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Seki, Chie"}],"nameIdentifiers":[{"nameIdentifier":"818233","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tagai, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"818234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"818235","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamura, Soichiro"}],"nameIdentifiers":[{"nameIdentifier":"818236","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"818237","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichise, Masanori"}],"nameIdentifiers":[{"nameIdentifier":"818238","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Maiko"}],"nameIdentifiers":[{"nameIdentifier":"818239","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahata, Keisuke"}],"nameIdentifiers":[{"nameIdentifier":"818240","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kubota, Manabu"}],"nameIdentifiers":[{"nameIdentifier":"818241","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takado, Yuhei"}],"nameIdentifiers":[{"nameIdentifier":"818242","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada, Maki"}],"nameIdentifiers":[{"nameIdentifier":"818243","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kikuchi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"818244","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang"}],"nameIdentifiers":[{"nameIdentifier":"818245","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"818246","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"818247","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seki, Chie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818248","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tagai, Kenji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818249","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818250","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamura, Soichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818251","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818252","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichise, Masanori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818253","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Maiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818254","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahata, Keisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818255","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kubota, Manabu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818256","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takado, Yuhei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818257","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada, Maki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kikuchi, Tatsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818262","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Establishment of a simplified method to quantify [18F]PM-PBB3 ([18F]APN-1607) binding in the brains of living human subjects","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Establishment of a simplified method to quantify [18F]PM-PBB3 ([18F]APN-1607) binding in the brains of living human subjects"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-12-25"},"publish_date":"2019-12-25","publish_status":"0","recid":"78239","relation_version_is_last":true,"title":["Establishment of a simplified method to quantify [18F]PM-PBB3 ([18F]APN-1607) binding in the brains of living human subjects"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:23:01.469859+00:00"}