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Influence of dose-averaged linear energy transfer on tumor control after carbon-ion radiation therapy for pancreatic cancer
https://repo.qst.go.jp/records/78221
https://repo.qst.go.jp/records/78221fe9c5a03-3ab5-4040-b09c-fe651bd98e00
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-12-23 | |||||
| タイトル | ||||||
| タイトル | Influence of dose-averaged linear energy transfer on tumor control after carbon-ion radiation therapy for pancreatic cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hagiwara, Yasuhito
× Hagiwara, Yasuhito× Bhattacharyya, Tapesh× Matsufuji, Naruhiro× Isozaki, Yuka× Takiyama, Hirotoshi× Nemoto, Kenji× Tsuji, Hiroshi× Yamada, Shigeru× Yasuhito, Hagiwara× Bhattacharyya, Tapesh× Naruhiro, Matsufuji× Yuka, Isozaki× Hirotoshi, Takiyama× Kenji, Nemoto× Hiroshi, Tsuji× Shigeru, Yamada |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background and purpose High linear energy transfer (LET) radiation carbon-ion radiotherapy (C-ion RT) is one of the most promising modalities for treating unresectable primary pancreatic cancers. However, how LET contributes to a therapeutic effect is not clear. To assess whether there is an enhanced effect of high LET radiation on tumour control, we aimed to determine the impact of dose-averaged LET on local control (LC) of primary pancreatic tumours. Materials and methods A retrospective analysis of 18 patients with primary pancreatic carcinomas treated with definitive C-ion RT with concurrent chemotherapy in 2013 was conducted. The dose of irradiation was 55.2 Gy (RBE). The relationship between dose-averaged LET and LC of primary tumours was evaluated. Results All patients had histologically confirmed adenocarcinoma. The median follow-up duration was 22 months. The actuarial LC and overall survival (OS) at 18 months were 62.5% and 70.1%, respectively. There were no cases of grade ≥3 late toxicities observed. Local recurrences developed in four patients (22%), all of which were infield central recurrences. Although there were no significant differences in gross tumour volume (GTV) dose coverage, patients with higher minimum dose-averaged LET (LETmin) values within the GTV had better LC (dose-averaged LETmin ≥44 keV/microm; 18-months LC 100.0% vs 34.3%; p = 0.0366). Conclusion Dose-averaged LETmin within the GTV was significantly associated with LC of primary pancreatic cancers. Our data suggest that outcomes for patients with unresectable primary pancreatic cancers receiving C-ion RT can be improved by modulating the dose-averaged LET within the GTV. |
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| 書誌情報 |
Clinical and Translational Radiation Oncology 巻 21, p. 19-24, 発行日 2020-03 |
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| 出版者 | ||||||
| 出版者 | ELSEVIER | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2405-6308 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.ctro.2019.11.002 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S2405630819301090 | |||||
