{"created":"2023-05-15T14:57:38.092931+00:00","id":78221,"links":{},"metadata":{"_buckets":{"deposit":"e550b324-2c0a-46ff-b774-c397bb35318e"},"_deposit":{"created_by":1,"id":"78221","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"78221"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00078221","sets":["1"]},"author_link":["1001899","1001887","1001890","1001902","1001901","1001894","1001889","1001888","1001892","1001891","1001896","1001897","1001900","1001898","1001895","1001893"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"24","bibliographicPageStart":"19","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"Clinical and Translational Radiation Oncology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and purpose\nHigh linear energy transfer (LET) radiation carbon-ion radiotherapy (C-ion RT) is one of the most promising modalities for treating unresectable primary pancreatic cancers. However, how LET contributes to a therapeutic effect is not clear. To assess whether there is an enhanced effect of high LET radiation on tumour control, we aimed to determine the impact of dose-averaged LET on local control (LC) of primary pancreatic tumours.\nMaterials and methods\nA retrospective analysis of 18 patients with primary pancreatic carcinomas treated with definitive C-ion RT with concurrent chemotherapy in 2013 was conducted. The dose of irradiation was 55.2 Gy (RBE). The relationship between dose-averaged LET and LC of primary tumours was evaluated.\nResults\nAll patients had histologically confirmed adenocarcinoma. The median follow-up duration was 22 months. The actuarial LC and overall survival (OS) at 18 months were 62.5% and 70.1%, respectively. There were no cases of grade ≥3 late toxicities observed. Local recurrences developed in four patients (22%), all of which were infield central recurrences. Although there were no significant differences in gross tumour volume (GTV) dose coverage, patients with higher minimum dose-averaged LET (LETmin) values within the GTV had better LC (dose-averaged LETmin ≥44 keV/microm; 18-months LC 100.0% vs 34.3%; p = 0.0366).\nConclusion\nDose-averaged LETmin within the GTV was significantly associated with LC of primary pancreatic cancers. Our data suggest that outcomes for patients with unresectable primary pancreatic cancers receiving C-ion RT can be improved by modulating the dose-averaged LET within the GTV.\n","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ELSEVIER"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ctro.2019.11.002","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S2405630819301090","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2405-6308","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hagiwara, Yasuhito"}],"nameIdentifiers":[{"nameIdentifier":"1001887","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bhattacharyya, Tapesh"}],"nameIdentifiers":[{"nameIdentifier":"1001888","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsufuji, Naruhiro"}],"nameIdentifiers":[{"nameIdentifier":"1001889","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Isozaki, Yuka"}],"nameIdentifiers":[{"nameIdentifier":"1001890","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takiyama, Hirotoshi"}],"nameIdentifiers":[{"nameIdentifier":"1001891","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nemoto, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"1001892","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"1001893","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"1001894","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuhito, Hagiwara","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1001895","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bhattacharyya, Tapesh","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1001896","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naruhiro, Matsufuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1001897","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuka, Isozaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1001898","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirotoshi, Takiyama","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1001899","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kenji, Nemoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1001900","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroshi, Tsuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1001901","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shigeru, Yamada","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1001902","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Influence of dose-averaged linear energy transfer on tumor control after carbon-ion radiation therapy for pancreatic cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Influence of dose-averaged linear energy transfer on tumor control after carbon-ion radiation therapy for pancreatic cancer"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-12-23"},"publish_date":"2019-12-23","publish_status":"0","recid":"78221","relation_version_is_last":true,"title":["Influence of dose-averaged linear energy transfer on tumor control after carbon-ion radiation therapy for pancreatic cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:36:05.358478+00:00"}