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Microdosimetric study at the NIRS scanning beam for the multi-ion therapy
https://repo.qst.go.jp/records/77875
https://repo.qst.go.jp/records/778759d6a9e0c-b94b-442c-92f4-1c4e33fc6665
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-12-09 | |||||
| タイトル | ||||||
| タイトル | Microdosimetric study at the NIRS scanning beam for the multi-ion therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sung Hyun, Lee
× Sung Hyun, Lee× Mizushima, Kota× Sakata, Dousatsu× Sakama, Makoto× Kohno, Ryosuke× Iwata, Yoshiyuki× Shirai, Toshiyuki× Suzuki, Masao× Inaniwa, Taku× Sung-Hyun, Lee× Mizushima, Kota× Sakata, Dousatsu× Sakama, Makoto× Kohno, Ryosuke× Iwata, Yoshiyuki× Shirai, Toshiyuki× Suzuki, Masao× Inaniwa, Taku |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Microdosimetry with the microdosimetric kinetic (MK) model is a method to estimate the biological effects of the radiations which measures the dose absorbed by a micrometer-sized volume, namely a specific energy. The MK model developed by National Institute of Radiological Sciences (NIRS) is currently the world's standard biological model for calculating biological effects, which is known to be very good for carbon ions. NIRS recently announced a multi-ion treatment plan to produce better tumor outcomes from increasing the LET in tumors. This plan will use helium, carbon, oxygen and neon ions to treat pancreatic cancer. To estimate biological effect in multi-ion therapy, we measured lineal energy spectra of each ion by using the silicon- on-insulator (SOI) microdosimeter with well-defined 3D-sensitive volumes (SV) developed by the Centre for Medical Radiation Physics (CMRP) at the University of Wollongong. The 166, 313, 374, 430 MeV/u of each pristine helium, carbon, oxygen and neon ions were irradiated to the SOI microdosimeter of different depth in PMMA to obtain the microdosimetric spectra. The parameters of the MK model were then obtained by optimizing the result with the survival curves obtained by irradiating the human pancreatic carcinoma (Mia PaCa-2) with each of four ions and fitting them to the LQ model. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 1st Annual Conference of the Particle Therapy Co-operative Group Asia-Oceania (PTCOG-AO＇19) | |||||
| 発表年月日 | ||||||
| 日付 | 2019-12-07 | |||||
| 日付タイプ | Issued | |||||
