@misc{oai:repo.qst.go.jp:00077875,
 author = {Sung Hyun, Lee and Mizushima, Kota and Sakata, Dousatsu and Sakama, Makoto and Kohno, Ryosuke and Iwata, Yoshiyuki and Shirai, Toshiyuki and Suzuki, Masao and Inaniwa, Taku and Sung-Hyun, Lee and Mizushima, Kota and Sakata, Dousatsu and Sakama, Makoto and Kohno, Ryosuke and Iwata, Yoshiyuki and Shirai, Toshiyuki and Suzuki, Masao and Inaniwa, Taku},
 month = {Dec},
 note = {Microdosimetry with the microdosimetric kinetic (MK) model is a method to estimate the biological effects of the radiations which measures the dose absorbed by a micrometer-sized volume, namely a specific energy. The MK model developed by National Institute of Radiological Sciences (NIRS) is currently the world's standard biological model for calculating biological effects, which is known to be very good for carbon ions. NIRS recently announced a multi-ion treatment plan to produce better tumor outcomes from increasing the LET in tumors. This plan will use helium, carbon, oxygen and neon ions to treat pancreatic cancer. To estimate biological effect in multi-ion therapy, we measured lineal energy spectra of each ion by using the silicon- on-insulator (SOI) microdosimeter with well-defined 3D-sensitive volumes (SV) developed by the Centre for Medical Radiation Physics (CMRP) at the University of Wollongong. The 166, 313, 374, 430 MeV/u of each pristine helium, carbon, oxygen and neon ions were irradiated to the SOI microdosimeter of different depth in PMMA to obtain the microdosimetric spectra. The parameters of the MK model were then obtained by optimizing the result with the survival curves obtained by irradiating the human pancreatic carcinoma (Mia PaCa-2) with each of four ions and fitting them to the LQ model., The 1st Annual Conference of the Particle Therapy Co-operative Group Asia-Oceania (PTCOG-AO＇19)},
 title = {Microdosimetric study at the NIRS scanning beam for the multi-ion therapy},
 year = {2019}
}