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Model building of overlapping dinucleosome based on SAXS and SANS profiles
https://repo.qst.go.jp/records/77823
https://repo.qst.go.jp/records/77823e4ca0589-d04b-48fe-a31d-3d4cfb3b552b
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-11-13 | |||||
| タイトル | ||||||
| タイトル | Model building of overlapping dinucleosome based on SAXS and SANS profiles | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Atsushi
× Matsumoto, Atsushi× Matsumoto, Atsushi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Recently, the X-ray crystal structure of the overlapping dinucleosome was solved. However, it may be different from the structure in solution. Thus, we built the atomic models of the overlapping dinucleosome in solution based on the experimental profiles of the small-angle X-ray scattering (SAXS) and the small-angle neutron scattering (SANS) by the computational approach. We first generated a lot of atomic models of the di-nucleosome with different conformations by computer simulations using the X-ray crystal structure as the initial model. Then, the SAXS and SANS profiles were computed for each model. Finally, these computed profiles were compared with the experimental ones to find the appropriate models. For the accurate reproduction of the experimental data, it was important to model the histone tails, which were missing in the X-ray crystal structure. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第3回QST国際シンポジウム | |||||
| 発表年月日 | ||||||
| 日付 | 2019-12-04 | |||||
| 日付タイプ | Issued | |||||
