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Dose the enhancement of cell-killing effect in human cells irradiated with carbon-ion beams by applying longitudinal magnetic field relate to cellular response in the cells pre-irradiated cytoplasm with low-LET radiations?
https://repo.qst.go.jp/records/77466
https://repo.qst.go.jp/records/774661abf1829-7fc8-46bf-8f92-9da1e03498ef
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-11-18 | |||||
| タイトル | ||||||
| タイトル | Dose the enhancement of cell-killing effect in human cells irradiated with carbon-ion beams by applying longitudinal magnetic field relate to cellular response in the cells pre-irradiated cytoplasm with low-LET radiations? | |||||
| タイトル | ||||||
| タイトル | 平行磁場併用による炭素イオンビームの細胞致死効果増強と細胞質へのエネルギー付与による細胞応答の関係 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
鈴木, 雅雄
× 鈴木, 雅雄× 稲庭, 拓× 宇佐美, 徳子× 佐藤, 眞二× 野田, 章× 村松, 正幸× 岩田, 佳之× 兼松, 伸幸× 白井, 敏之× 野田, 耕司× Suzuki, Masao× Inaniwa, Taku× Sato, Shinji× Noda, Akira× Muramatsu, Masayuki× Iwata, Yoshiyuki× Kanematsu, Nobuyuki× Shirai, Toshiyuki× Noda, Koji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Technical innovation in radiation science enable us to develop the new therapies, such as the stereotactic irradiation, the adaptive radiation therapy of the intensity-modulated radiation therapy and the image-guided radiation therapy. They make it possible to deliver the ideal distribution of radiation doses to the target volume with great accuracy, sparing the neighboring normal organs at risk. It should be necessary for developing radiotherapy to understand fundamental biological responses concerning the combined effects between static magnetic fields and radiations. In this study we examined the cell-killing effect by carbon-ion irradiations in combination with static magnetic fields. Normal human skin fibroblasts and cervical epitheloid carcinoma cells were irradiated with carbon ions (LET~ 12 and 50keV/µm) accelerated with the Heavy Ion Medical Accelerator in Chiba under the longitudinal magnetic fields of 0, 0.3 and 0.6 T generated by a solenoid magnet. The cell-killing effects, which were detected using the colony-forming assay, treated with the magnetic fields of 0.3T and 0.6T during the irradiations were 1.3 ~ 1.5 times higher than those of carbon ions alone. There is evidence that the carbon-ion induced cell death is enhanced by combining with the longitudinal magnetic fields. We set up the hypothesis from the data using X-ray microbeams generated with the synchrotron radiations at Photon Factory as follows; “When cytoplasm of targeted cells are irradiated with low-LET radiations, unknown cellular response(s) is induced in the cell and in consequence the cell becomes protective to radiation damage.” We will discuss a possible mechanism based on our hypothesis. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第62回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-11-14 | |||||
| 日付タイプ | Issued | |||||
