@misc{oai:repo.qst.go.jp:00077466,
 author = {鈴木, 雅雄 and 稲庭, 拓 and 宇佐美, 徳子 and 佐藤, 眞二 and 野田, 章 and 村松, 正幸 and 岩田, 佳之 and 兼松, 伸幸 and 白井, 敏之 and 野田, 耕司 and Suzuki, Masao and Inaniwa, Taku and Sato, Shinji and Noda, Akira and Muramatsu, Masayuki and Iwata, Yoshiyuki and Kanematsu, Nobuyuki and Shirai, Toshiyuki and Noda, Koji},
 month = {Nov},
 note = {Technical innovation in radiation science enable us to develop the new therapies, such as the stereotactic irradiation, the adaptive radiation therapy of the intensity-modulated radiation therapy and the image-guided radiation therapy. They make it possible to deliver the ideal distribution of radiation doses to the target volume with great accuracy, sparing the neighboring normal organs at risk. It should be necessary for developing radiotherapy to understand fundamental biological responses concerning the combined effects between static magnetic fields and radiations. In this study we examined the cell-killing effect by carbon-ion irradiations in combination with static magnetic fields. Normal human skin fibroblasts and cervical epitheloid carcinoma cells were irradiated with carbon ions (LET~ 12 and 50keV/µm) accelerated with the Heavy Ion Medical Accelerator in Chiba under the longitudinal magnetic fields of 0, 0.3 and 0.6 T generated by a solenoid magnet. The cell-killing effects, which were detected using the colony-forming assay, treated with the magnetic fields of 0.3T and 0.6T during the irradiations were 1.3 ~ 1.5 times higher than those of carbon ions alone. There is evidence that the carbon-ion induced cell death is enhanced by combining with the longitudinal magnetic fields. We set up the hypothesis from the data using X-ray microbeams generated with the synchrotron radiations at Photon Factory as follows; “When cytoplasm of targeted cells are irradiated with low-LET radiations, unknown cellular response(s) is induced in the cell and in consequence the cell becomes protective to radiation damage.” We will discuss a possible mechanism based on our hypothesis., 日本放射線影響学会第62回大会},
 title = {Dose the enhancement of cell-killing effect in human cells irradiated with carbon-ion beams by applying longitudinal magnetic field relate to cellular response in the cells pre-irradiated cytoplasm with low-LET radiations?},
 year = {2019}
}