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Irradiation is effective treatment to SLE-like morbidity in NZBWF1 mice
https://repo.qst.go.jp/records/77449
https://repo.qst.go.jp/records/77449104ea5a0-43bf-4dd6-b628-487131353db7
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-04-02 | |||||
| タイトル | ||||||
| タイトル | Irradiation is effective treatment to SLE-like morbidity in NZBWF1 mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujita, Kazuko
× Fujita, Kazuko× Kuwabara, Taku× Wang, Bing× Tanaka, Kaoru× Y, Tome× Inada M× K, Ito× A, Tsukimoto× Y, Yoshida× Mikami T× Y , Akasaka× Fujita, Kazuko× Kuwabara, Taku× Wang, Bing× Tanaka, Kaoru |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Mature B cell expressing CD180 molecules was first reported showing a protective effect against radiation- or dexamethasone-induced apoptosis in vitro. CD180 is a homologue of toll-like receptor (TLR) 4 and a pivotal regulator of cell proliferation and death. In SLE patients, number of CD180-negative B cells showed to increase in peripheral blood, and the change in the number of CD180-negative B cells appeared to be associated with the activity of SLE. In addition, such negative cells collected from SLE patients produced autoantibodies in vitro. We previously showed that the radiosensitivity of CD180-negative cells was greater than that of CD180-positive cells in vivo. In SLE-model NZBWF1 mice, we also reported the increase in number of CD180-negative B cells in parallel with development of SLE morbidity, the production of autoantibodies by CD180-negative cells, and pathogenesis of lupus-like nephritis caused by CD180-negative cells. We therefore, here, examine the effects of Xray-irradiation targeted CD180-negative B cells in NZBWF1 female mice. After the onset of symptoms, mice were paired according to their conditions. In each pair, one was irradiated with 4 Gy, and the other was sham-irradiated. Compared to the sham-irradiated mice, the number of CD180-negative cells was significantly decreased, the mean life span was markedly extended, and the nephritis and the morbid conditions were remarkably suppressed in irradiated mice. These findings suggest that radiation could effectively eliminate CD180-negative B cells, resulting in reduction of autoantibody production, and thus relieve SLE-like morbidity in SLE-model NZBWF1 mice. The findings also suggest a possibility that the radiotherapy for autoimmune diseases associated with the expression of CD180-negative cells, such as SLE and Sögren syndrome, might be a novel candidate for practical application. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 16th International Congress of Radiation Research (ICRR2019） | |||||
| 発表年月日 | ||||||
| 日付 | 2019-08-29 | |||||
| 日付タイプ | Issued | |||||
