@misc{oai:repo.qst.go.jp:00077449,
 author = {Fujita, Kazuko and Kuwabara, Taku and Wang, Bing and Tanaka, Kaoru and Y, Tome and Inada M and K, Ito and A, Tsukimoto and Y, Yoshida and Mikami T and Y , Akasaka and Fujita, Kazuko and Kuwabara, Taku and Wang, Bing and Tanaka, Kaoru},
 month = {Aug},
 note = {Mature B cell expressing CD180 molecules was first reported showing a protective effect against radiation- or dexamethasone-induced apoptosis in vitro. CD180 is a homologue of toll-like receptor (TLR) 4 and a pivotal regulator of cell proliferation and death. In SLE patients, number of CD180-negative B cells showed to increase in peripheral blood, and the change in the number of CD180-negative B cells appeared to be associated with the activity of SLE. In addition, such negative cells collected from SLE patients produced autoantibodies in vitro. We previously showed that the radiosensitivity of CD180-negative cells was greater than that of CD180-positive cells in vivo. In SLE-model NZBWF1 mice, we also reported the increase in number of CD180-negative B cells in parallel with development of SLE morbidity, the production of autoantibodies by CD180-negative cells, and pathogenesis of lupus-like nephritis caused by CD180-negative cells. We therefore, here, examine the effects of Xray-irradiation targeted CD180-negative B cells in NZBWF1 female mice. After the onset of symptoms, mice were paired according to their conditions. In each pair, one was irradiated with 4 Gy, and the other was sham-irradiated. Compared to the sham-irradiated mice, the number of CD180-negative cells was significantly decreased, the mean life span was markedly extended, and the nephritis and the morbid conditions were remarkably suppressed in irradiated mice. These findings suggest that radiation could effectively eliminate CD180-negative B cells, resulting in reduction of autoantibody production, and thus relieve SLE-like morbidity in SLE-model NZBWF1 mice. The findings also suggest a possibility that the radiotherapy for autoimmune diseases associated with the expression of CD180-negative cells, such as SLE and Sögren syndrome, might be a novel candidate for practical application., The 16th International Congress of Radiation Research (ICRR2019）},
 title = {Irradiation is effective treatment to SLE-like morbidity in NZBWF1 mice},
 year = {2019}
}