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正常マウスにおける123I-MIBGと211At-MABGの体内動態の評価
https://repo.qst.go.jp/records/77442
https://repo.qst.go.jp/records/77442111b2e4e-cd1a-4c5d-b43a-d8fe3e6121fd
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-11-15 | |||||
| タイトル | ||||||
| タイトル | 正常マウスにおける123I-MIBGと211At-MABGの体内動態の評価 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
趙, 松吉
× 趙, 松吉× 吉永, 恵一郎× 粟生木, 美穂× 右近, 直之× 下山, 彩希× 西嶋, 剣一× 鷲山, 幸信× 鷲野, 弘明× 高橋, 和弘× 東, 達也× 伊藤, 浩× Zhao, Songji× Yoshinaga, Keiichiro× Aoki, Miho× Ukon, Naoyuki× Nishijima, Kenichi× Koushin, Washiyama× Washino, Komei× Higashi, Tatsuya× Ito, Hiroshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The alpha-emitting radiopharmaceutical meta-[211At]astatobenzylguanidine (211At-MABG) has potential as a metastatic pheochromocytoma treatment. As 211At-MABG does not emit gamma-rays suitable for dosimetry and imaging, 211At-MABG needs a companion diagnostic imaging agent such as meta-[123I]iodobenzylguanidine (123I-MIBG) to be used in making treatment decisions. We evaluated the similarities and differences between 123I-MIBG and 211At-MABG in biodistribution in normal mice. BALB/c mice were injected with 123I-MIBG or 211At-MABG, and the radioactivity levels (%ID/g) in the tissues were determined at 1 and 30 min, and 1, 3, 6, and 24 h after the injection. Results: 211At-MABG and 123I-MIBG showed very similar biodistribution profiles in normal mice at every time point. Conclusions: 123I-MIBG can be used for dosimetry and imaging for decisions regarding treatment with 211At-MABG radiotherapy. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第59回日本核医学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-11-02 | |||||
| 日付タイプ | Issued | |||||
