WEKO3
アイテム
Translesion synthesis in plants: ultraviolet resistance and beyond
https://repo.qst.go.jp/records/77109
https://repo.qst.go.jp/records/771093d1b3b38-a064-4c11-a758-94e1e39e2ff2
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-08-01 | |||||
| タイトル | ||||||
| タイトル | Translesion synthesis in plants: ultraviolet resistance and beyond | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sakamoto, Ayako
× Sakamoto, Ayako× Ayako, Sakamoto |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Plant genomes sustain various forms of DNA damage that stall replication forks. Translesion synthesis (TLS) is one of the pathways to overcome stalled replication, in which specific polymerases (TLS polymerase) perform bypass synthesis across DNA damage. This article gives a brief overview of plant TLS polymerases. In Arabisopsis, DNA polymerase (Pol) ζ, η, κ, θ, λ and Reversionless1 (Rev1) are shown to be involved in the TLS. In general, TLS polymerases have low fidelity and often induce mutations. Disruption of AtPolζ or AtRev1 reduces somatic mutation frequency, whereas disruption of AtPolη elevates it, suggesting that plants have both mutagenic and less mutagenic TLS activities. Hypersensitivities of TLS-deficient plants to γ-ray suggest that plant TLS polymerases have multiple roles. | |||||
| 書誌情報 |
Frontiers in Plant Science 巻 10, p. 1208, 発行日 2019-10 |
|||||
| 出版者 | ||||||
| 出版者 | Frontiers | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1664-462X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3389/fpls.2019.01208 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.frontiersin.org/research-topics/8851/the-maintenance-of-genome-integrity-in-plants-novel-challenges-in-basic-and-applied-research | |||||
