WEKO3
アイテム
Function of non-coding RNAs in regulating heavy-ion induced biological effects. (17J329-FY2018)
https://repo.qst.go.jp/records/75683
https://repo.qst.go.jp/records/756834e74f352-e736-4f4b-9482-aa7e351571c3
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-04-18 | |||||
| タイトル | ||||||
| タイトル | Function of non-coding RNAs in regulating heavy-ion induced biological effects. (17J329-FY2018) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Zou, Guangming
× Zou, Guangming× Pei, Hailong× Li, Bingyan× Furusawa, Yoshiya× Hirayama, Ryoichi× Konishi, Teruaki× Furusawa, Yoshiya× Hirayama, Ryoichi× Konishi, Teruaki |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The dynamic interchange between monomeric globular actin (G-actin) and polymeric filamentous actin filaments (F-actin) is fundamental to cell motility and cytokinesis. However, there are few literatures elucidating the regulation of long noncoding RNAs (lncRNA) in -actin dynamic. Here we characterize a lncRNA: LNC CRYBG3 and we confirmed a physical and functional interaction between LNC CRYBG3 and -actin whichsuppresses G-actin polymerization. During HIMAC experiment, we found a heavy ion radiation sensitived LncRNA CRYBG3 and it’s overexpression caused tumor cells’ survival rate decreased for 72%. Therefore, we hypothesized that lncRNA CRYBG3 regulates heavy ion induced apoptosis by targeting Actin-MAL-SRF pathway. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成30年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告会 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-04-22 | |||||
| 日付タイプ | Issued | |||||
