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Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation
https://repo.qst.go.jp/records/75640
https://repo.qst.go.jp/records/75640b2b441ec-d492-44fb-bb46-5ba835934e13
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-04-15 | |||||
| タイトル | ||||||
| タイトル | Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kuan, Hu
× Kuan, Hu× Hanyu, Masayuki× Xie, Lin× Zhang, Yiding× Nagatsu, Kotaro× Suzuki, Hisashi× Ming-Rong, Zhang× Kuan, Hu× Hanyu, Masayuki× Xie, Lin× Zhang, Yiding× Nagatsu, Kotaro× Suzuki, Hisashi× Ming-Rong, Zhang |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Herein, a PD-L1 targeted native peptide was developed for PET imaging. 18F and 64Cu were utilized to label the peptide. To improve the pharmacokinetics and biodistribution of the tracers, the peptide was further pegylated to form star-like tetramers. Consequently, four tracers were synthesized with acceptable radiochemical characteristics and their in vivo pharmacokinetics and PD-L1 imaging capability were systematically evaluated. This proof-of-principle study may provide new possibilities for PD-L1 PET imaging in cancers. |
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| 書誌情報 |
Chemical Communications 巻 55, 号 29, p. 4162-4165, 発行日 2019-02 |
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| 出版者 | ||||||
| 出版者 | Royal Society of Chemistry | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1359-7345 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1039/c9cc00445a | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://pubs.rsc.org/en/content/articlelanding/2019/cc/c9cc00445a#!divAbstract | |||||
