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Mouse intestinal Lgr5+ stem cells are more sensitive to heavy ion irradiation than Bmi1+ stem cells
https://repo.qst.go.jp/records/75233
https://repo.qst.go.jp/records/75233861511fe-ad39-4fa9-b5af-c97b2c1bd9b9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-03-18 | |||||
| タイトル | ||||||
| タイトル | Mouse intestinal Lgr5+ stem cells are more sensitive to heavy ion irradiation than Bmi1+ stem cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wu, Anqing
× Wu, Anqing× Hu, Wentao× Zhang, Jian× Ziyang, Guo× Liu, Cuihua× Katsube, Takanori× Tanaka, Kaoru× Jing Nie× Wang, Bing× Zhou, Guangming× Wu, Anqing× Hu, Wentao× Zhang, Jian× Ziyang, Guo× Liu, Cuihua× Katsube, Takanori× Tanaka, Kaoru× Wang, Bing× Zhou, Guangming |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Before the human exploration of the Mars or other long-duration missions in outer space, the risks of cancer and other radiation injury induced by space radiations, containing high linear energy transfer (LET) particles such as heavy ions, must be accurately estimated and mitigated. On the other hand, accelerated carbon ions have been successfully used for clinical tumor treatment, and their damages to normal tissues are also of concern. Therefore, heavy ion particles are severely risky not only to manned space exploration but also to the patients experiencing particle radiotherapy [1,2]. Earlier studies suggested that intestine was a radio-sensitive tissue which was seriously injured, and then lost main digestion absorption function for individual survival after low LET radiation such as γ-rays and X-rays. But there is much uncertainty in understanding heavy-ion-induced intestinal injury because sufficient in vivo mechanistic data are not available. Here, we demonstrate for the first time that the Bmi1-expressing cells are more resistant to carbon ions than Lgr5+ cells in mouse intestine and may be the major stem cells for the self-renewal of intestinal cells after intestinal injury induced by carbon ion irradiation. |
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| 書誌情報 |
Acta Biochimica et Biophysica Sinica. 巻 51, 号 3, p. 338-340, 発行日 2019-03 |
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| 出版者 | ||||||
| 出版者 | Oxford University Pressオックスフォード大学出版局 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1745-7270 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/abbs/gmy158 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://academic.oup.com/abbs/article-abstract/51/3/338/5253207 | |||||
