@article{oai:repo.qst.go.jp:00075233,
 author = {Wu, Anqing and Hu, Wentao and Zhang, Jian and Ziyang, Guo and Liu, Cuihua and Katsube, Takanori and Tanaka, Kaoru and Jing Nie and Wang, Bing and Zhou, Guangming and Wu, Anqing and Hu, Wentao and Zhang, Jian and Ziyang, Guo and Liu, Cuihua and Katsube, Takanori and Tanaka, Kaoru and Wang, Bing and Zhou, Guangming},
 issue = {3},
 journal = {Acta Biochimica et Biophysica Sinica.},
 month = {Mar},
 note = {Before the human exploration of the Mars or other long-duration missions in outer space, the risks of cancer and other radiation injury induced by space radiations, containing high linear energy transfer (LET) particles such as heavy ions, must be accurately estimated and mitigated. On the other hand, accelerated carbon ions have been successfully used for clinical tumor treatment, and their damages to normal tissues are also of concern. Therefore, heavy ion particles are severely risky not only to manned space exploration but also to the patients experiencing particle radiotherapy [1,2].
Earlier studies suggested that intestine was a radio-sensitive tissue which was seriously injured, and then lost main digestion absorption function for individual survival after low LET radiation such as γ-rays and X-rays. But there is much uncertainty in understanding heavy-ion-induced intestinal injury because sufficient in vivo mechanistic data are not available. Here, we demonstrate for the first time that the Bmi1-expressing cells are more resistant to carbon ions than Lgr5+ cells in mouse intestine and may be the major stem cells for the self-renewal of intestinal cells after intestinal injury induced by carbon ion irradiation.},
 pages = {338--340},
 title = {Mouse intestinal Lgr5+ stem cells are more sensitive to heavy ion irradiation than Bmi1+ stem cells},
 volume = {51},
 year = {2019}
}