WEKO3
アイテム
In vivo uptake of 18F-PM-PBB3 in patients with diverse 4-repeat tauopathies
https://repo.qst.go.jp/records/74881
https://repo.qst.go.jp/records/748815689b758-918d-41e0-a8dd-357f9e9d51bd
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-03-20 | |||||
| タイトル | ||||||
| タイトル | In vivo uptake of 18F-PM-PBB3 in patients with diverse 4-repeat tauopathies | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
島田, 斉
× 島田, 斉× Shimada, Hitoshi |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: Abnormal accumulations of tau proteins are pathognomonic hallmarks of 4-repeat tauopathies represented by progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). The aim of this study is to investigate the characteristic pattern of 18F-PM-PBB3 uptake and its relationship with clinical symptoms and neurodegeneration in patients with clinically diagnosed patients with 4-repeat tauopathies. Methods: 17 patients with 4-repeat tauopathies, including PSP-Richardson syndrome (PSP-RS), PSP-parkinsonism (PSP-P), PSP-progressive non-fluent aphasia (PSP-PNFA), PSP-behavior variant frontotemporal dementia (PSP-bvFTD), corticobasal syndrome-progressive non-fluent aphasia (CBS-PNFA), and biopsy-confirmed CBD, were recruited. Seven Alzheimer’s disease (AD) spectrum patients and 29 cognitively healthy controls (HCs) were also enrolled. All participants underwent PET scans with 18F-PM-PBB3 and 11C-PiB for evaluating regional tau and Aβ depositions. Parametric 18F-PM-PBB3- and 11C-PiB- images were generated by voxel-based calculation of standard standardized uptake value ratio (SUVR) to the cerebellum. Results: PiB-negative patients with 4-repeat tauopathies showed remarkable uptake of PM-PBB3 especially around subthalamic nucleus, basal ganglia and brainstem. Compared with PSP-RS, patients with PSP-P and CBD showed relatively milder PM-PBB3 uptake around brainstem. In contrast, patients with 4-repeat tauopathies having verbal and/or behavior symptoms presented elevated PM-PBB3 uptake also in some cortices. Patients with 4-repeat tauopathies were easily differentiated from AD spectrum patients as well as HCs both by visual assessment and quantitative comparison of SUVR values in some brain regions. Conclusions: Accumulations of PM-PBB3 would reflect characteristic distributions of tau pathologies in 4-repeat tauopathies. The present study would provide further evidence for the potential utility of 18F-PM-PBB3 PET in tracking 4-repeat tau pathologies. |
|||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ADPD2019 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-03-31 | |||||
| 日付タイプ | Issued | |||||
