{"created":"2023-05-15T14:55:05.821411+00:00","id":74881,"links":{},"metadata":{"_buckets":{"deposit":"82c564cf-df85-482d-b7f7-4b3c7511a31d"},"_deposit":{"created_by":1,"id":"74881","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"74881"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00074881","sets":["10:29"]},"author_link":["740041","740042"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-03-31","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: \nAbnormal accumulations of tau proteins are pathognomonic hallmarks of 4-repeat tauopathies represented by progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). The aim of this study is to investigate the characteristic pattern of 18F-PM-PBB3 uptake and its relationship with clinical symptoms and neurodegeneration in patients with clinically diagnosed patients with 4-repeat tauopathies.\nMethods: \n17 patients with 4-repeat tauopathies, including PSP-Richardson syndrome (PSP-RS), PSP-parkinsonism (PSP-P), PSP-progressive non-fluent aphasia (PSP-PNFA), PSP-behavior variant frontotemporal dementia (PSP-bvFTD), corticobasal syndrome-progressive non-fluent aphasia (CBS-PNFA), and biopsy-confirmed CBD, were recruited. Seven Alzheimer’s disease (AD) spectrum patients and 29 cognitively healthy controls (HCs) were also enrolled. All participants underwent PET scans with 18F-PM-PBB3 and 11C-PiB for evaluating regional tau and Aβ depositions. Parametric 18F-PM-PBB3- and 11C-PiB- images were generated by voxel-based calculation of standard standardized uptake value ratio (SUVR) to the cerebellum.\nResults: \nPiB-negative patients with 4-repeat tauopathies showed remarkable uptake of PM-PBB3 especially around subthalamic nucleus, basal ganglia and brainstem. Compared with PSP-RS, patients with PSP-P and CBD showed relatively milder PM-PBB3 uptake around brainstem. In contrast, patients with 4-repeat tauopathies having verbal and/or behavior symptoms presented elevated PM-PBB3 uptake also in some cortices. Patients with 4-repeat tauopathies were easily differentiated from AD spectrum patients as well as HCs both by visual assessment and quantitative comparison of SUVR values in some brain regions.\nConclusions: \nAccumulations of PM-PBB3 would reflect characteristic distributions of tau pathologies in 4-repeat tauopathies. The present study would provide further evidence for the potential utility of 18F-PM-PBB3 PET in tracking 4-repeat tau pathologies.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"ADPD2019","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"島田, 斉"}],"nameIdentifiers":[{"nameIdentifier":"740041","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"740042","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"In vivo uptake of 18F-PM-PBB3 in patients with diverse 4-repeat tauopathies","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In vivo uptake of 18F-PM-PBB3 in patients with diverse 4-repeat tauopathies"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-20"},"publish_date":"2019-03-20","publish_status":"0","recid":"74881","relation_version_is_last":true,"title":["In vivo uptake of 18F-PM-PBB3 in patients with diverse 4-repeat tauopathies"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T07:33:53.781146+00:00"}