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A Small Fish Model for Quantitative Analysis of Radiation Effects Using Visualized Thymus Responses in GFP Transgenic Medaka.
https://repo.qst.go.jp/records/74853
https://repo.qst.go.jp/records/74853b59f9b45-c839-44f8-8c5f-73d6b1d9bcc7
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-02-27 | |||||
| タイトル | ||||||
| タイトル | A Small Fish Model for Quantitative Analysis of Radiation Effects Using Visualized Thymus Responses in GFP Transgenic Medaka. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Maruyama, Kouichi
× Maruyama, Kouichi× Iwanami , Norimasa× Takako, Maruyama-Hayakawa× Doi, Kazutaka× Wang, Bing× Kouichi, Maruyama× Kazutaka, Doi× Bing, Wang |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: The aim of this study was to establish a new method of real-time, in vivo detection of radiation damage and recovery. Methods: The thymus was observed under fluorescent light in a green fluorescent protein transgenic medaka. After irradiation, medaka thymus images were analyzed to quantify the effects of radiation by measuring changes in thymus size. A single acute irradiation of X-rays (0–30 Gy) or heavy Fe ions (0–10 Gy) was delivered to the medaka. Images were captured 0, 1, 2, 3, 5, 7, 11, and 21 days after irradiation. Dose-response assessment was conducted to provide a direct measurement of the effects of the radiation. Conclusion: A biomonitoring system to detect the effects of radiation in real time was established. Using this system, the threshold doses for the induction of thymic atrophy by acute X-rays and Fe ions were 2–5 Gy and 0.5–1 Gy, respectively. The Relative Biological Effectiveness (RBE) of Fe-ion to X-rays was estimated to be around 3. This system may be used to evaluate the risk from concurrent exposure to hazards, such as chemicals and radiation, and for aging research. |
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| 書誌情報 |
International journal of radiation biology 巻 95, 号 8, p. 1144-1149, 発行日 2019-03 |
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| 出版者 | ||||||
| 出版者 | Taylor and Francis | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0955-3002 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1080/09553002.2019.1589019 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1589019 | |||||
