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Kinetic Isotope Effect in the Scavenging Reaction of a Water-Solubilized Organic Radical by a Vitamin E Analog
https://repo.qst.go.jp/records/74846
https://repo.qst.go.jp/records/74846ac8af64e-c5bc-46cf-9a46-4eafeed60cbe
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-01-15 | |||||
| タイトル | ||||||
| タイトル | Kinetic Isotope Effect in the Scavenging Reaction of a Water-Solubilized Organic Radical by a Vitamin E Analog | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakanishi, Ikuo
× Nakanishi, Ikuo× Ohkubo, Kei× Ozawa, Toshihiko× Ken-ichiro, Matsumoto× Nakanishi, Ikuo× Ohkubo, Kei× Ozawa, Toshihiko× Matsumoto, Kenichiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Vitamin E is known to efficiently scavenge reactive oxygen species and related radicals via hydrogen transfer from its phenolic hydroxy group. However, the detailed reaction mechanism has yet to be fully clarified. In this study, the kinetic isotope effect was investigated for the reaction of Trolox, a water soluble vitamin E analog, with 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical solubilized by beta-cyclodextrin in water. A deuterium kinetic isotope effect of 5.0 was observed in 0.1 M BIS-TRIS buffer (pH/pD 6.9). The DPPH radical-scavenging mechanism of Trolox will be discussed on the basis of the effect of pH and solvents on the second-order rate constants observed in this study. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本化学会第99春季年会 | |||||
| 発表年月日 | ||||||
| 日付 | 2019-03-17 | |||||
| 日付タイプ | Issued | |||||
