ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 原著論文

Anti-tumor effects and potential therapeutic response biomarkers in alpha-emitting meta-At-211-astato-benzylguanidine therapy for malignant pheochromocytoma explored by RNA-sequencing

https://repo.qst.go.jp/records/73849
https://repo.qst.go.jp/records/73849
3821dcdd-dc10-4a5a-8dc2-f8c45b035cd8
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-02-27
タイトル
タイトル Anti-tumor effects and potential therapeutic response biomarkers in alpha-emitting meta-At-211-astato-benzylguanidine therapy for malignant pheochromocytoma explored by RNA-sequencing
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 大島, 康宏

× 大島, 康宏

WEKO 872905

大島, 康宏

Search repository
河野, 暢明

× 河野, 暢明

WEKO 872906

河野, 暢明

Search repository
横田, 裕一郎

× 横田, 裕一郎

WEKO 872907

横田, 裕一郎

Search repository
渡辺, 茂樹

× 渡辺, 茂樹

WEKO 872908

渡辺, 茂樹

Search repository
佐々木, 一郎

× 佐々木, 一郎

WEKO 872909

佐々木, 一郎

Search repository
石岡, 典子

× 石岡, 典子

WEKO 872910

石岡, 典子

Search repository
坂下, 哲哉

× 坂下, 哲哉

WEKO 872911

坂下, 哲哉

Search repository
荒川, 和晴

× 荒川, 和晴

WEKO 872912

荒川, 和晴

Search repository
Oshima, Yasuhiro

× Oshima, Yasuhiro

WEKO 872913

en Oshima, Yasuhiro

Search repository
Yokota, Yuuichiro

× Yokota, Yuuichiro

WEKO 872914

en Yokota, Yuuichiro

Search repository
Watanabe, Shigeki

× Watanabe, Shigeki

WEKO 872915

en Watanabe, Shigeki

Search repository
Sasaki, Ichiro

× Sasaki, Ichiro

WEKO 872916

en Sasaki, Ichiro

Search repository
Ishioka, Noriko

× Ishioka, Noriko

WEKO 872917

en Ishioka, Noriko

Search repository
Sakashita, Tetsuya

× Sakashita, Tetsuya

WEKO 872918

en Sakashita, Tetsuya

Search repository
抄録
内容記述タイプ Abstract
内容記述 Targeted α-particle therapy is a promising option for patients with malignant pheochromocytoma. Recent observations regarding meta-211At-astato-benzylguanidine (211At-MABG) in a pheochromocytoma mouse model showed a strong anti-tumor effect, though the molecular mechanism remains elusive. Here, we present the first comprehensive RNA-sequencing (RNA-seq) data for pheochromocytoma cells based on in vitro 211At-MABG administration experiments. Key genes and pathways in the tumor α-particle radiation response are also examined to obtain potential response biomarkers.
Methods: We evaluated genome-wide transcriptional alterations in the rat pheochromocytoma cell line PC12 at 3, 6, and 12 h after 211At-MABG treatment; a control experiment using 60Co γ-ray irradiation was carried out to highlight 211At-MABG-specific gene expression. For comparisons, 10% and 80% iso-survival doses (0.8 and 0.1 kBq/mL for 211At-MABG and 10 and 1 Gy for 60Co γ-rays) were used.
Results: Enrichment analysis of differentially expressed genes (DEGs) and analysis of the gene expression profiles of cell cycle checkpoints revealed similar modes of cell death via the p53-p21 signaling pathway after 211At-MABG treatment and γ-ray irradiation. The top list of ranked DEGs demonstrated the expression of key genes on the decrease in the survival following 211At-MABG exposure, and four potential genes (Mien1, Otub1, Vdac1 and Vegfa genes) of 211At-MABG therapy. Western blot analysis indicated increased expression of TSPO in 211At-MABG-treated cells, suggesting its potential as a PET imaging probe.
Conclusion: Comprehensive RNA-seq revealed contrasting cellular responses to γ-ray and α-particle therapy, leading to the identification of four potential candidate genes that may serve as molecular imaging and 211At-MABG therapy targets.
書誌情報 Theranostics

巻 9, 号 6, 発行日 2019-03
出版者
出版者 IVYSPRING
ISSN
収録物識別子タイプ ISSN
収録物識別子 1838-7640
DOI
識別子タイプ DOI
関連識別子 10.7150/thno.30353
戻る
0
views
See details
Views

Versions

Ver.1 2023-05-15 18:06:19.233819
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3