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Treatment of oral cancer using magnetized paclitaxel.
https://repo.qst.go.jp/records/73840
https://repo.qst.go.jp/records/73840919c50e3-705d-4cd9-a9d0-e33329a6a273
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-02-25 | |||||
| タイトル | ||||||
| タイトル | Treatment of oral cancer using magnetized paclitaxel. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakakaji, Rina
× Nakakaji, Rina× Umemura, Masanari× Mitsudo, Kenji× Jeong-Hwan, Kim× Hoshino, Yujiro× Sato, Itaru× Masuda, Takatsugu× Yamamoto, Masahiro× Kioi, Mitomu× Koizumi, Toshiyuki× Fujita, Takayuki× Yokoyama, Utako× Iida, Masaki× Sato, Motohiko× Sato, Hiroshi× Murofushi, Shoko× Shibata, Sayaka× Aoki, Ichio× Eguchi, Haruki× Tohnai, Iwai× Ishikawa, Yoshihiro× Nakakaji, Rina× Umemura, Masanari× Sato, Itaru× Sato, Hiroshi× Shibata, Sayaka× Aoki, Ichio |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | (Fe(Salen)) is an anti-cancer agent with intrinsic magnetic property. Here, we covalently linked Fe(Salen) to paclitaxel (PTX), a widely used anti-cancer drug, to obtain a magnetized paclitaxel conjugate (M-PTX), which exhibited magnetic characteristics for magnet-guided drug delivery and MRI visualization. M-PTX increased apoptosis and G2/M arrest of cultured human oral cancer cell lines in the same manner as PTX. Furthermore, marked contrast intensity was obtained in magnetic resonance imaging (MRI) of M-PTX. In a mouse oral cancer model, a permanent magnet placed on the body surface adjacent to the tumor resulted in distinct accumulation of M-PTX, and the anti-cancer effect was greater than that of M-PTX without the magnet. We believe that this strategy may improve future cancer chemotherapy by providing conventional anti-cancer drugs with novel functionalities such as magnet-guided drug delivery or MRI-based visualization/quantitation of drug distribution. | |||||
| 書誌情報 |
Oncotarget 巻 9, 号 21, p. 15591-15605, 発行日 2019-02 |
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| 出版者 | ||||||
| 出版者 | Impact Journals | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1949-2553 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29643995 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.18632/oncotarget.24570 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=24570&path[]=77103 | |||||
