{"created":"2023-05-15T14:54:20.114082+00:00","id":73840,"links":{},"metadata":{"_buckets":{"deposit":"ebad98c1-18f0-4361-bc5f-31f902cfecb9"},"_deposit":{"created_by":1,"id":"73840","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"73840"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00073840","sets":["1"]},"author_link":["814347","814362","814356","814372","814360","814361","814358","814369","814352","814364","814366","814355","814367","814359","814371","814363","814350","814370","814353","814357","814365","814351","814348","814349","814354","814368","814373"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"21","bibliographicPageEnd":"15605","bibliographicPageStart":"15591","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Oncotarget"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":" (Fe(Salen)) is an anti-cancer agent with intrinsic magnetic property. Here, we covalently linked Fe(Salen) to paclitaxel (PTX), a widely used anti-cancer drug, to obtain a magnetized paclitaxel conjugate (M-PTX), which exhibited magnetic characteristics for magnet-guided drug delivery and MRI visualization. M-PTX increased apoptosis and G2/M arrest of cultured human oral cancer cell lines in the same manner as PTX. Furthermore, marked contrast intensity was obtained in magnetic resonance imaging (MRI) of M-PTX. In a mouse oral cancer model, a permanent magnet placed on the body surface adjacent to the tumor resulted in distinct accumulation of M-PTX, and the anti-cancer effect was greater than that of M-PTX without the magnet. We believe that this strategy may improve future cancer chemotherapy by providing conventional anti-cancer drugs with novel functionalities such as magnet-guided drug delivery or MRI-based visualization/quantitation of drug distribution.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":" Impact Journals"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29643995","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.18632/oncotarget.24570","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=24570&path[]=77103","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1949-2553","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only 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Takatsugu"}],"nameIdentifiers":[{"nameIdentifier":"814353","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"814354","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kioi, Mitomu"}],"nameIdentifiers":[{"nameIdentifier":"814355","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koizumi, Toshiyuki"}],"nameIdentifiers":[{"nameIdentifier":"814356","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujita, Takayuki"}],"nameIdentifiers":[{"nameIdentifier":"814357","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokoyama, Utako"}],"nameIdentifiers":[{"nameIdentifier":"814358","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iida, Masaki"}],"nameIdentifiers":[{"nameIdentifier":"814359","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Motohiko"}],"nameIdentifiers":[{"nameIdentifier":"814360","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"814361","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murofushi, Shoko"}],"nameIdentifiers":[{"nameIdentifier":"814362","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Sayaka"}],"nameIdentifiers":[{"nameIdentifier":"814363","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"814364","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Eguchi, Haruki"}],"nameIdentifiers":[{"nameIdentifier":"814365","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tohnai, Iwai"}],"nameIdentifiers":[{"nameIdentifier":"814366","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Yoshihiro"}],"nameIdentifiers":[{"nameIdentifier":"814367","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakakaji, Rina","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"814368","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Umemura, Masanari","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"814369","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Itaru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"814370","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"814371","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Sayaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"814372","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"814373","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Treatment of oral cancer using magnetized paclitaxel.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Treatment of oral cancer using magnetized paclitaxel."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-25"},"publish_date":"2019-02-25","publish_status":"0","recid":"73840","relation_version_is_last":true,"title":["Treatment of oral cancer using magnetized paclitaxel."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:29:05.298014+00:00"}