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Age Dependence of Radiation-Induced Genomic Instability in Mouse Hematopoietic Stem Cells
https://repo.qst.go.jp/records/73441
https://repo.qst.go.jp/records/73441f24f0ea1-3076-43e7-8d0b-e4cc33212042
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-02-22 | |||||
| タイトル | ||||||
| タイトル | Age Dependence of Radiation-Induced Genomic Instability in Mouse Hematopoietic Stem Cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ariyoshi, Kentaro
× Ariyoshi, Kentaro× Miura, Tomisato× Kasai, Kosuke× Akifumi, Nakata× Fujishima, Yohei× Shinagawa, Mayumi× Kadono, Kyoko× Nishimura, Mayumi× Kakinuma, Shizuko× A. Yoshida, Mitsuaki× Ariyoshi, Kentaro× Shinagawa, Mayumi× Kadono, Kyoko× Nishimura, Mayumi× Kakinuma, Shizuko× Yoshida, Mitsuaki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Age at exposure is a critical factor that influences the risk of radiation-induced leukemia. Accumulating evidence suggests that ionizing radiation can induce genomic instability and promote leukemogenesis in hematopoietic stem cells (HSCs); however, the influence of age on this phenomenon has not been elucidated. In this study, infant (1-week-old) or adult (14-week-old) C3H/He mice received sham or 4 Gy whole-body irradiation, and bone marrow cells were transplanted to recipients at day 1 or 60 postirradiation. Twelve days after bone marrow transplant, we analyzed the radiation-induced genomic instability by scoring the frequency of DNA damage and micronucleus formation in colony-forming units-spleen (CFU-Ss). We observed significant increases in DNA damage and micronucleus formation in CFU-Ss of the 4 Gy irradiated adult cells transplanted at day 1 or 60 postirradiation. However, the frequency of DNA damage focus and micronucleus formation in CFU-Ss of 4 Gy irradiated infant cells transplanted at day 1 or 60 postirradiation was relatively decreased. Quantitative differences in the reactive oxygen species and cells expressing inducible nitric oxide synthase in CFU-Ss suggested that age-dependent radiation-induced genomic instability may result from chronic oxidative stress by pro-inflammatory states in HSC descendants after radiation exposure. | |||||
| 書誌情報 |
Radiation Research 巻 190, 号 6, p. 623-633, 発行日 2018-10 |
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| 出版者 | ||||||
| 出版者 | Radiation Research Society | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1667/RR15113.1 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1667/RR15113.1 | |||||
