{"created":"2023-05-15T14:53:56.148980+00:00","id":73441,"links":{},"metadata":{"_buckets":{"deposit":"a57c9999-4cbe-47e3-8ff4-fc1a5ce9054a"},"_deposit":{"created_by":1,"id":"73441","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"73441"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00073441","sets":["1"]},"author_link":["759719","759722","759714","759725","759726","759721","759713","759712","759711","759716","759723","759715","759718","759724","759720","759717"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"633","bibliographicPageStart":"623","bibliographicVolumeNumber":"190","bibliographic_titles":[{"bibliographic_title":"Radiation Research "}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Age at exposure is a critical factor that influences the risk of radiation-induced leukemia. Accumulating evidence suggests that ionizing radiation can induce genomic instability and promote leukemogenesis in hematopoietic stem cells (HSCs); however, the influence of age on this phenomenon has not been elucidated. In this study, infant (1-week-old) or adult (14-week-old) C3H/He mice received sham or 4 Gy whole-body irradiation, and bone marrow cells were transplanted to recipients at day 1 or 60 postirradiation. Twelve days after bone marrow transplant, we analyzed the radiation-induced genomic instability by scoring the frequency of DNA damage and micronucleus formation in colony-forming units-spleen (CFU-Ss). We observed significant increases in DNA damage and micronucleus formation in CFU-Ss of the 4 Gy irradiated adult cells transplanted at day 1 or 60 postirradiation. However, the frequency of DNA damage focus and micronucleus formation in CFU-Ss of 4 Gy irradiated infant cells transplanted at day 1 or 60 postirradiation was relatively decreased. Quantitative differences in the reactive oxygen species and cells expressing inducible nitric oxide synthase in CFU-Ss suggested that age-dependent radiation-induced genomic instability may result from chronic oxidative stress by pro-inflammatory states in HSC descendants after radiation exposure.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Radiation Research Society"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1667/RR15113.1 ","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1667/RR15113.1","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0033-7587","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ariyoshi, Kentaro"}],"nameIdentifiers":[{"nameIdentifier":"759711","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miura, Tomisato"}],"nameIdentifiers":[{"nameIdentifier":"759712","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kasai, Kosuke"}],"nameIdentifiers":[{"nameIdentifier":"759713","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akifumi, Nakata"}],"nameIdentifiers":[{"nameIdentifier":"759714","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujishima, Yohei"}],"nameIdentifiers":[{"nameIdentifier":"759715","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinagawa, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"759716","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kadono, Kyoko"}],"nameIdentifiers":[{"nameIdentifier":"759717","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"759718","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"759719","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"A. Yoshida, Mitsuaki"}],"nameIdentifiers":[{"nameIdentifier":"759720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ariyoshi, Kentaro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"759721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinagawa, Mayumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"759722","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kadono, Kyoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"759723","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"759724","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"759725","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Mitsuaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"759726","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Age Dependence of Radiation-Induced Genomic Instability in Mouse Hematopoietic Stem Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Age Dependence of Radiation-Induced Genomic Instability in Mouse Hematopoietic Stem Cells"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-22"},"publish_date":"2019-02-22","publish_status":"0","recid":"73441","relation_version_is_last":true,"title":["Age Dependence of Radiation-Induced Genomic Instability in Mouse Hematopoietic Stem Cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:44:35.937798+00:00"}