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Computational analysis of bystander signaling in cellular population irradiated with microbeam
https://repo.qst.go.jp/records/73322
https://repo.qst.go.jp/records/733220246af81-4338-4a49-9176-75934a00af7e
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-03-28 | |||||
| タイトル | ||||||
| タイトル | Computational analysis of bystander signaling in cellular population irradiated with microbeam | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
服部, 佑哉
× 服部, 佑哉× 横谷, 明徳× 倉林, 大輔× 渡辺, 立子× 横谷 明徳× 横谷 立子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Even when only a limited number of cells in a population are irradiated with spatially limited ionizing radiation, such as microbeam, unexposed cells could also be affected by receiving certain intercellular signals from the irradiated cells. This "bystander effects" has been intensively studied from the point of view of low-dose radiation risk. To investigate detailed mechanism of the unique non-targeting effects, we analyzed the characteristics of the bystander signaling among the cells using a mathematical model, which consists of several simple functions describing production of intercellular signal molecules, DNA damage induction, or cell death. We evaluated these functions by fitting simulation results to experimental ones in a previous report. Linear and non-linear characteristics of bystander signaling were revealed by analysis of typical radiation response of bystander effects. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第55回日本生物物理学会年回 | |||||
| 発表年月日 | ||||||
| 日付 | 2017-09-21 | |||||
| 日付タイプ | Issued | |||||
