@misc{oai:repo.qst.go.jp:00073322, author = {服部, 佑哉 and 横谷, 明徳 and 倉林, 大輔 and 渡辺, 立子 and 横谷 明徳 and 横谷 立子}, month = {Sep}, note = {Even when only a limited number of cells in a population are irradiated with spatially limited ionizing radiation, such as microbeam, unexposed cells could also be affected by receiving certain intercellular signals from the irradiated cells. This "bystander effects" has been intensively studied from the point of view of low-dose radiation risk. To investigate detailed mechanism of the unique non-targeting effects, we analyzed the characteristics of the bystander signaling among the cells using a mathematical model, which consists of several simple functions describing production of intercellular signal molecules, DNA damage induction, or cell death. We evaluated these functions by fitting simulation results to experimental ones in a previous report. Linear and non-linear characteristics of bystander signaling were revealed by analysis of typical radiation response of bystander effects., 第55回日本生物物理学会年回}, title = {Computational analysis of bystander signaling in cellular population irradiated with microbeam}, year = {2017} }