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Imaging diverse tau fibril strains in tauopathies
https://repo.qst.go.jp/records/73230
https://repo.qst.go.jp/records/732305fffa910-cd03-42cd-b1ad-8c9a19485973
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-04-20 | |||||
| タイトル | ||||||
| タイトル | Imaging diverse tau fibril strains in tauopathies | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Higuchi, Makoto
× Higuchi, Makoto× Shimada, Hitoshi× Sahara, Naruhiko× Maruyama, Masahiro× Shinotoh, Hitoshi× Zhang, Ming-Rong× Suhara, Tetsuya× 樋口 真人× 島田 斉× 佐原 成彦× 丸山 将浩× 篠遠 仁× 張 明栄× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Visualization of fibrillar tau aggregates in Alzheimer’s disease (AD) and other tauopathies including frontotemporal lobar degeneration (FTLD) provides insights into roles of tau deposition in neurodegeneration, and a diagnostic adjunct to these illnesses. We recently developed a positron emission tomographic (PET) imaging agent for tau lesions, PBB3, and demonstrated its capability in detecting tau accumulation in diverse tauopathies. PBB3-PET also indicated spreading of tau pathology from the hippocampal formation to extensive neocortical areas in transition from normal aging to advanced AD. In FTLD patients, distributions of PBB3 retention differed between progressive supranuclear palsy (PSP) and corticobasal syndrome, and were also distinct from those in AD. Furthermore, PET and autoradiography with PBB3 have revealed regionality of PBB3-positive tau deposition in a manner characteristic of familial tau gene mutations. Notably, PBB3 and various other tau ligands displayed differential reactivity with tau aggregates in FTLDs. These data support the presence of distinct strains of tau fibrils presumably attributed to different isoform compositions and mutations of tau as well as interactions of tau with non-tau aggregates, and the same non-mutant tau isoforms may also produce minor conformational variations in PSP and corticobasal degeneration. These strains define regional, cellular and subcellular localization of tau inclusions, and would be identified in living brains using a set of tau PET ligands. PBB3 may be utilized as a versatile ligand reacting with tau lesions in the vast majority of tauopathies, and development of its fluorinated derivatives aimed at a wider use is in progress. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 9th International Conference on Frontotemporal Dementias | |||||
| 発表年月日 | ||||||
| 日付 | 2014-10-23 | |||||
| 日付タイプ | Issued | |||||
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Higuchi, Makoto, Shimada, Hitoshi, Sahara, Naruhiko, Maruyama, Masahiro, Shinotoh, Hitoshi, Zhang, Ming-Rong, Suhara, Tetsuya, 樋口 真人, 島田 斉, 佐原 成彦, 丸山 将浩, 篠遠 仁, 張 明栄, 須原 哲也, 2014, Imaging diverse tau fibril strains in tauopathies.
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