@misc{oai:repo.qst.go.jp:00073230,
 author = {Higuchi, Makoto and Shimada, Hitoshi and Sahara, Naruhiko and Maruyama, Masahiro and Shinotoh, Hitoshi and Zhang, Ming-Rong and Suhara, Tetsuya and 樋口 真人 and 島田 斉 and 佐原 成彦 and 丸山 将浩 and 篠遠 仁 and 張 明栄 and 須原 哲也},
 month = {Oct},
 note = {Visualization of fibrillar tau aggregates in Alzheimer’s disease (AD) and other tauopathies including frontotemporal lobar degeneration (FTLD) provides insights into roles of tau deposition in neurodegeneration, and a diagnostic adjunct to these illnesses. We recently developed a positron emission tomographic (PET) imaging agent for tau lesions, PBB3, and demonstrated its capability in detecting tau accumulation in diverse tauopathies. PBB3-PET also indicated spreading of tau pathology from the hippocampal formation to extensive neocortical areas in transition from normal aging to advanced AD. In FTLD patients, distributions of PBB3 retention differed between progressive supranuclear palsy (PSP) and corticobasal syndrome, and were also distinct from those in AD. Furthermore, PET and autoradiography with PBB3 have revealed regionality of PBB3-positive tau deposition in a manner characteristic of familial tau gene mutations. Notably, PBB3 and various other tau ligands displayed differential reactivity with tau aggregates in FTLDs. These data support the presence of distinct strains of tau fibrils presumably attributed to different isoform compositions and mutations of tau as well as interactions of tau with non-tau aggregates, and the same non-mutant tau isoforms may also produce minor conformational variations in PSP and corticobasal degeneration. These strains define regional, cellular and subcellular localization of tau inclusions, and would be identified in living brains using a set of tau PET ligands. PBB3 may be utilized as a versatile ligand reacting with tau lesions in the vast majority of tauopathies, and development of its fluorinated derivatives aimed at a wider use is in progress., 9th International Conference on Frontotemporal Dementias},
 title = {Imaging diverse tau fibril strains in tauopathies},
 year = {2014}
}