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Protective effects of p53-regulating agents against high-LET radiation-induced injury in mice
https://repo.qst.go.jp/records/73009
https://repo.qst.go.jp/records/730099acd2d08-e710-4136-92f6-1c294d3acc24
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-11-13 | |||||
| タイトル | ||||||
| タイトル | Protective effects of p53-regulating agents against high-LET radiation-induced injury in mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nishiyama, Yuichi
× Nishiyama, Yuichi× Morita, Akinori× Wang, Bing× Tanaka, Kaoru× Katsube, Takanori× Murakami, Masahiro× Ochi Shintaro× Ramadhani, Dwi× Teraoka, Tatsuro× Shimokawa, Takashi× Nenoi, Mitsuru× Shin, Aoki× 王 冰× 田中 薫× 勝部 孝則× 村上 正弘× 越智 進太郎× Ramadhani Dwi× 下川 卓志× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation damage to normal tissues is one of the most serious concerns in radiation therapy, and the tolerance dose of the normal tissues limits the therapeutic dose to the patients. p53 is well known as a transcription factor closely associated with radiation-induced cell death. We recently demonstrated the protective effects of several p53-regulating agents against low-LET X- or γ-ray-induced damage: Sodium orthovanadate (vanadate) markedly rescued mice from bone marrow death following total-body X-irradiation through inhibition of p53 activity, and 5-chloro-8-quinolinol (5CHQ) effectively suppressed the intestinal death in the abdominally irradiated mice via modulation of p53 transactivation. Although it was reported that high-LET heavy ion radiation (> 85 keV/μm) could cause p53-independent cell death in some cancer cell lines, whether there is any radioprotective effect of the p53-regulating agents against the high-LET radiation injury in vivo is still unclear. In the present study we verified and confirmed the efficacy of these agents on bone marrow and intestinal damages induced by high-LET carbon-ion irradiation in mice. Vanadate dramatically improved 60-day survival rate in mice treated with total-body carbon-ion irradiation, indicating its effective protection of the hematopoietic system from radiation injury. 5CHQ slightly increased the survival rate after abdominal irradiation, suggesting the moderate relief of the intestinal damage. More detailed investigation is currently in progress to clarify the mechanisms involved in protecting the mice from high-LET radiation. \n |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 国際セミナー・ワークショップ ”Technological Competency as Caring in the Health Sciences: A seminar and workshop”. | |||||
| 発表年月日 | ||||||
| 日付 | 2018-08-17 | |||||
| 日付タイプ | Issued | |||||
