@misc{oai:repo.qst.go.jp:00073009,
 author = {Nishiyama, Yuichi and Morita, Akinori and Wang, Bing and Tanaka, Kaoru and Katsube, Takanori and Murakami, Masahiro and Ochi Shintaro and Ramadhani, Dwi and Teraoka, Tatsuro and Shimokawa, Takashi and Nenoi, Mitsuru and Shin, Aoki and 王 冰 and 田中 薫 and 勝部 孝則 and 村上 正弘 and 越智 進太郎 and Ramadhani Dwi and 下川 卓志 and 根井 充},
 month = {Aug},
 note = {Radiation damage to normal tissues is one of the most serious concerns in radiation therapy, and the tolerance dose of the normal tissues limits the therapeutic dose to the patients. p53 is well known as a transcription factor closely associated with radiation-induced cell death. We recently demonstrated the protective effects of several p53-regulating agents against low-LET X- or γ-ray-induced damage: Sodium orthovanadate (vanadate) markedly rescued mice from bone marrow death following total-body X-irradiation through inhibition of p53 activity, and 5-chloro-8-quinolinol (5CHQ) effectively suppressed the intestinal death in the abdominally irradiated mice via modulation of p53 transactivation. Although it was reported that high-LET heavy ion radiation (> 85 keV/μm) could cause p53-independent cell death in some cancer cell lines, whether there is any radioprotective effect of the p53-regulating agents against the high-LET radiation injury in vivo is still unclear. In the present study we verified and confirmed the efficacy of these agents on bone marrow and intestinal damages induced by high-LET carbon-ion irradiation in mice. Vanadate dramatically improved 60-day survival rate in mice treated with total-body carbon-ion irradiation, indicating its effective protection of the hematopoietic system from radiation injury. 5CHQ slightly increased the survival rate after abdominal irradiation, suggesting the moderate relief of the intestinal damage. More detailed investigation is currently in progress to clarify the mechanisms involved in protecting the mice from high-LET radiation.
\n, 国際セミナー・ワークショップ　”Technological Competency as Caring in the Health Sciences: A seminar and workshop”.},
 title = {Protective effects of p53-regulating agents against high-LET radiation-induced injury in mice},
 year = {2018}
}