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Synthesis and evaluation of novel positron emission tomography probe for metabotropic glutamate receptor 5
https://repo.qst.go.jp/records/72942
https://repo.qst.go.jp/records/72942ff5330af-39ac-49f8-b716-916aded45ee5
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-09-19 | |||||
| タイトル | ||||||
| タイトル | Synthesis and evaluation of novel positron emission tomography probe for metabotropic glutamate receptor 5 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ishii, Hideki
× Ishii, Hideki× Yamasaki, Tomoteru× Zhang, Yiding× Zhang, Ming-Rong× 石井 英樹× 山崎 友照× 張 一鼎× 張 明栄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The novel highly potent biologically stable metabotropic glutamate receptor 5 (mGlu5) selective positron emission tomography (PET) probes, [11C]-3-fluoro-5-(5-(pyridin-2-yl)-2H-tetrazol-2-yl)benzonitrile ([11C]FPTB) and [11C]-3-(5-(pyridin-2-yl)-2H-tetrazol-2-yl)benzonitrile ([11C]PTB), have been developed using Pd-mediated [11C]cyanation of 2-(2-(3-bromo-5-fluorophenyl)-2H-tetrazol-5-yl)pyridine (Br-FPTB) or 2-(2-(3-bromophenyl)-2H-tetrazol-5-yl)pyridine (Br-PTB). The elaboration of the reaction conditions and evaluation of these 11C-labeled probes (([11C]FPTB) and ([11C]PTB)) will be discussed. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | WMIC2018(World Molecular Imaging Congress)でのポスター発表 | |||||
| 発表年月日 | ||||||
| 日付 | 2018-09-15 | |||||
| 日付タイプ | Issued | |||||
