@misc{oai:repo.qst.go.jp:00072942, author = {Ishii, Hideki and Yamasaki, Tomoteru and Zhang, Yiding and Zhang, Ming-Rong and 石井 英樹 and 山崎 友照 and 張 一鼎 and 張 明栄}, month = {Sep}, note = {The novel highly potent biologically stable metabotropic glutamate receptor 5 (mGlu5) selective positron emission tomography (PET) probes, [11C]-3-fluoro-5-(5-(pyridin-2-yl)-2H-tetrazol-2-yl)benzonitrile ([11C]FPTB) and [11C]-3-(5-(pyridin-2-yl)-2H-tetrazol-2-yl)benzonitrile ([11C]PTB), have been developed using Pd-mediated [11C]cyanation of 2-(2-(3-bromo-5-fluorophenyl)-2H-tetrazol-5-yl)pyridine (Br-FPTB) or 2-(2-(3-bromophenyl)-2H-tetrazol-5-yl)pyridine (Br-PTB). The elaboration of the reaction conditions and evaluation of these 11C-labeled probes (([11C]FPTB) and ([11C]PTB)) will be discussed., WMIC2018(World Molecular Imaging Congress)でのポスター発表}, title = {Synthesis and evaluation of novel positron emission tomography probe for metabotropic glutamate receptor 5}, year = {2018} }