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Association between tau neuropathology in TBI patients and late-onset psychiatric symptoms: A PET study
https://repo.qst.go.jp/records/72929
https://repo.qst.go.jp/records/729297916b4d8-6ce5-421b-962e-3a167439f225
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-09-12 | |||||
| タイトル | ||||||
| タイトル | Association between tau neuropathology in TBI patients and late-onset psychiatric symptoms: A PET study | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
高畑, 圭輔
× 高畑, 圭輔× 木村, 泰之× 島田, 斉× 市瀬, 正則× 佐原, 成彦× 森口, 翔× 北村, 聡一郎× 久保田, 学× 水島 仁× 田渕, 肇× 河村, 和紀× 張, 明栄× 三村, 將× 須原, 哲也× 樋口, 真人× 高畑 圭輔× 木村 泰之× 島田 斉× 市瀬 正則× 佐原 成彦× 森口 翔× 北村 聡一郎× 久保田 学× 河村 和紀× 張 明栄× 三村 將× 須原 哲也× 樋口 真人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | [11C]PBB3 binding capacity [cm3] as a total volume of voxels whose binding potential values (BP*ND) above a threshold in a target region. Amyloid β depositions were evaluated by estimating standardized uptake value ratio (SUVR) for [11C]PiB between the entire cerebral cortex and cerebellar cortex. A cortical [11C]PiB SUVR above 1.21 was considered to be high uptake4. All PET scans were performed with a Bigograph mCT flow system (Siemens Healthcare, Erlangen, Germany). Psychiatric symptoms were evaluated by clinical scales and neuropsychological tests. RESULTS: TBI patients showed higher [11C]PBB3 binding capacities in the neocortical gray and white matter but not in the subcortical gray or subcortical white matter compared to controls. TBI patients with late-onset psychiatric symptoms had higher [11C]PBB3 binding capacities in the white matter compared to those without late-onset psychiatric symptoms. Among TBI patients, [11C]PBB3 binding capacity in the cortical and subcortical white matter showed positive correlation with severity of psychosis as assessed by Brief Psychiatric Rating Scale (BPRS). Among TBI patients and normal control subjects, only one single-severe TBI patients was [11C]PiB positive (cortical [11C]PiB PET SUVR: 1.32). Discussion/Conclusion: Our results provide the in vivo evidence of distinctive distribution of tau neuropathology in TBI brains. Late-onset symptoms following TBI are associated with higher tau depositions in the cortical white matter, implicating physical injury-provoked axonal tau accumulations in the deteriorations of the brain functions. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 12nd International Symposium of Functional Neuroreceptor Mapping of the Living Brain (NRM2018) | |||||
| 発表年月日 | ||||||
| 日付 | 2018-07-11 | |||||
| 日付タイプ | Issued | |||||
