@misc{oai:repo.qst.go.jp:00072929,
 author = {高畑, 圭輔 and 木村, 泰之 and 島田, 斉 and 市瀬, 正則 and 佐原, 成彦 and 森口, 翔 and 北村, 聡一郎 and 久保田, 学 and 水島 仁 and 田渕, 肇 and 河村, 和紀 and 張, 明栄 and 三村, 將 and 須原, 哲也 and 樋口, 真人 and 高畑 圭輔 and 木村 泰之 and 島田 斉 and 市瀬 正則 and 佐原 成彦 and 森口 翔 and 北村 聡一郎 and 久保田 学 and 河村 和紀 and 張 明栄 and 三村 將 and 須原 哲也 and 樋口 真人},
 month = {Jul},
 note = {[11C]PBB3 binding capacity [cm3] as a total volume of voxels whose binding potential values (BP*ND) above a threshold in a target region. Amyloid β depositions were evaluated by estimating standardized uptake value ratio (SUVR) for [11C]PiB between the entire cerebral cortex and cerebellar cortex. A cortical [11C]PiB SUVR above 1.21 was considered to be high uptake4. All PET scans were performed with a Bigograph mCT flow system (Siemens Healthcare, Erlangen, Germany). Psychiatric symptoms were evaluated by clinical scales and neuropsychological tests. 
RESULTS: TBI patients showed higher [11C]PBB3 binding capacities in the neocortical gray and white matter but not in the subcortical gray or subcortical white matter compared to controls. TBI patients with late-onset psychiatric symptoms had higher [11C]PBB3 binding capacities in the white matter compared to those without late-onset psychiatric symptoms. Among TBI patients, [11C]PBB3 binding capacity in the cortical and subcortical white matter showed positive correlation with severity of psychosis as assessed by Brief Psychiatric Rating Scale (BPRS). Among TBI patients and normal control subjects, only one single-severe TBI patients was [11C]PiB positive (cortical [11C]PiB PET SUVR: 1.32).
Discussion/Conclusion: Our results provide the in vivo evidence of distinctive distribution of tau neuropathology in TBI brains. Late-onset symptoms following TBI are associated with higher tau depositions in the cortical white matter, implicating physical injury-provoked axonal tau accumulations in the deteriorations of the brain functions., 12nd International Symposium of Functional Neuroreceptor Mapping of the Living Brain (NRM2018)},
 title = {Association between tau neuropathology in TBI patients and late-onset psychiatric symptoms: A PET study},
 year = {2018}
}