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Hyperpolarized [1-13C]pyruvate MRS reveals increased aerobic glycolysis in the ultra-early phase of PSA-negative prostate carcinogenesis
https://repo.qst.go.jp/records/72921
https://repo.qst.go.jp/records/72921bbe7e6d3-8593-4255-85ea-7c2a5378d188
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-09-10 | |||||
| タイトル | ||||||
| タイトル | Hyperpolarized [1-13C]pyruvate MRS reveals increased aerobic glycolysis in the ultra-early phase of PSA-negative prostate carcinogenesis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takakusagi, Yoichi
× Takakusagi, Yoichi× Takakusagi, Kaori× Inoue, Kaori× Ichikawa, Kazuhiro× 高草木 洋一× 高草木 香織 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopic imaging (MRSI) is a promising technique that allows noninvasive assessment of pyruvate conversion to lactate, which is significantly higher in the solid tumors [1]. First-in-human study for metabolic imaging of prostate cancer is ongoing [2]. Very recently, we have reported the use of this approach for noninvasive assessment of therapeutic response to LDH inhibitor for mice-bearing tumor xenografts of PSA-negative human prostate carcinoma (DU145, PC-3) [3]. In the present study, hyperpolarized [1-13C]pyruvate MRS was employed to detect metabolic alterations in the early phase of three-dimensional (3D) organization of these cells. \n[1] Day S.E. et al. Nat. Med. 13, 1382 (2007) [2] Nelson S.J. et al. Sci. Transl. Med. 5, 198ra108 (2013) [3] Scroggins B.T. et al. Clin. Cancer Res. 24, 3137 (2018) |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | HYP18 −An International Conference on Nuclear Hyperpolarization | |||||
| 発表年月日 | ||||||
| 日付 | 2018-09-04 | |||||
| 日付タイプ | Issued | |||||
