{"created":"2023-05-15T14:53:32.880813+00:00","id":72921,"links":{},"metadata":{"_buckets":{"deposit":"c8660ce2-95f2-45d9-825e-a65416834d0c"},"_deposit":{"created_by":1,"id":"72921","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"72921"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00072921","sets":["10:28"]},"author_link":["718547","718545","718546","718544","718548","718549"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-09-04","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopic imaging (MRSI) is a promising technique that allows noninvasive assessment of pyruvate conversion to lactate, which is significantly higher in the solid tumors [1]. First-in-human study for metabolic imaging of prostate cancer is ongoing [2]. Very recently, we have reported the use of this approach for noninvasive assessment of therapeutic response to LDH inhibitor for mice-bearing tumor xenografts of PSA-negative human prostate carcinoma (DU145, PC-3) [3]. In the present study, hyperpolarized [1-13C]pyruvate MRS was employed to detect metabolic alterations in the early phase of three-dimensional (3D) organization of these cells. \n\\n[1] Day S.E. et al. Nat. Med. 13, 1382 (2007)\n[2] Nelson S.J. et al. Sci. Transl. Med. 5, 198ra108 (2013)\n[3] Scroggins B.T. et al. Clin. Cancer Res. 24, 3137 (2018)","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"HYP18 −An International Conference on Nuclear Hyperpolarization","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takakusagi, Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"718544","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takakusagi, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"718545","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"718546","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichikawa, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"718547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高草木 洋一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"718548","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高草木 香織","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"718549","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Hyperpolarized [1-13C]pyruvate MRS reveals increased aerobic glycolysis in the ultra-early phase of PSA-negative prostate carcinogenesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hyperpolarized [1-13C]pyruvate MRS reveals increased aerobic glycolysis in the ultra-early phase of PSA-negative prostate carcinogenesis"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-09-10"},"publish_date":"2018-09-10","publish_status":"0","recid":"72921","relation_version_is_last":true,"title":["Hyperpolarized [1-13C]pyruvate MRS reveals increased aerobic glycolysis in the ultra-early phase of PSA-negative prostate carcinogenesis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:34:39.027634+00:00"}