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Evaluation of Poly-MVA as a new radio-protectant against high LET particle irradiation
https://repo.qst.go.jp/records/72749
https://repo.qst.go.jp/records/72749bd3d1da4-86f5-46e1-bc5c-d06b5f647e71
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-23 | |||||
| タイトル | ||||||
| タイトル | Evaluation of Poly-MVA as a new radio-protectant against high LET particle irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Zhou, Guangming
× Zhou, Guangming× Wang, Bing× Hirayama, Ryoichi× Wu, Anqing× Hu, Wentao× Zhang, Jian× Ziyang, Guo× Liu, Cuihua× Katsube, Takanori× Nenoi, Mitsuru× Li, Bingyan× Pei, Hailong× 周 光明× 王 冰× 平山 亮一× うー 安きん× 胡 文涛× 張 健× 郭 子揚× 劉 翠華× 勝部 孝則× 根井 充× 李 冰燕× Ｐｅｉ Ｈａｉｌｏｎｇ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Poly-MVA, a commercially available health supplement containing α-lipoic acid palladium complex, was evaluated for its potential in protecting mice from radiation-induced death. Treatment of 8 Gy X-ray-irradiated mice with Poly-MVA before and after exposure increased the survival rate from 60% to 100% 30 days after irradiation. The best efficacy was based on adequate absorption of Poly-MVA by a healthy mouse intestine. A dose higher than 8 Gy X-rays or 5.5 Gy carbon ions induced serious intestinal injury, which caused malabsorption of Poly-MVA. Poly-MVA treatment alone was ineffective to rescue mice exposed to a dose higher than 5.5 Gy of carbon ion irradiation. However, the synergistic radio-protective effect of Poly-MVA and amifostine was excellent on 9 Gy X-ray-irradiated mice. Combined administration of Poly-MVA and amifostine is expected to be useful in treating high LET particle-induced injury. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成29 年度HIMAC 共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2018-04-16 | |||||
| 日付タイプ | Issued | |||||
