@misc{oai:repo.qst.go.jp:00072749, author = {Zhou, Guangming and Wang, Bing and Hirayama, Ryoichi and Wu, Anqing and Hu, Wentao and Zhang, Jian and Ziyang, Guo and Liu, Cuihua and Katsube, Takanori and Nenoi, Mitsuru and Li, Bingyan and Pei, Hailong and 周 光明 and 王 冰 and 平山 亮一 and うー 安きん and 胡 文涛 and 張 健 and 郭 子揚 and 劉 翠華 and 勝部 孝則 and 根井 充 and 李 冰燕 and Pei Hailong}, month = {Apr}, note = {Poly-MVA, a commercially available health supplement containing α-lipoic acid palladium complex, was evaluated for its potential in protecting mice from radiation-induced death. Treatment of 8 Gy X-ray-irradiated mice with Poly-MVA before and after exposure increased the survival rate from 60% to 100% 30 days after irradiation. The best efficacy was based on adequate absorption of Poly-MVA by a healthy mouse intestine. A dose higher than 8 Gy X-rays or 5.5 Gy carbon ions induced serious intestinal injury, which caused malabsorption of Poly-MVA. Poly-MVA treatment alone was ineffective to rescue mice exposed to a dose higher than 5.5 Gy of carbon ion irradiation. However, the synergistic radio-protective effect of Poly-MVA and amifostine was excellent on 9 Gy X-ray-irradiated mice. Combined administration of Poly-MVA and amifostine is expected to be useful in treating high LET particle-induced injury., 平成29 年度HIMAC 共同利用研究成果発表会}, title = {Evaluation of Poly-MVA as a new radio-protectant against high LET particle irradiation}, year = {2018} }