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細胞死制御剤による重粒子放射線防護効果のマウス個体レベルでの検討
https://repo.qst.go.jp/records/72748
https://repo.qst.go.jp/records/7274845a05cab-aed6-4975-b145-cddfdd0b7f84
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-23 | |||||
| タイトル | ||||||
| タイトル | 細胞死制御剤による重粒子放射線防護効果のマウス個体レベルでの検討 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Akinori, Morita
× Akinori, Morita× Wang, Bing× Tanaka, Kaoru× Katsube, Takanori× Murakami, Masahiro× ラマダーニ・ドゥウィ× Shimokawa, Takashi× Nenoi, Mitsuru× Ochi Shintaro× 森田 明典× 王 冰× 田中 薫× 勝部 孝則× 村上 正弘× 下川 卓志× 根井 充× 越智 進太郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The remarkable progress toward high-precision radiation therapy has been made in recent years. However, in order to prevent adverse events occurring in organs at risk, the risks of radiation injury in the normal tissues still determine the limits of the tolerable dose. We explored some compounds that target p53, and found several radioprotectors that control p53 activity. On the other hand, it is known that high LET radia6on above 85 keV/μm shows a p53-independent cell killing effect on some cultured cells; however, there is no report so far about the radioprptective effects of p53 regulatory agents on heavy ion-irradiated mice. In this study, we used two p53 regulatory agents. One is a p53 inhibitor, sodium orthovanadate (vanadate), which has a potent radioprotective activity for bone marrow death in total body irradiated mice, and the other a transcriptional modulator for p53, 5-chloro-8-quinolinol (5CHQ), having a potent radioprotective ac6vity for gastrointestinal death in abdominally irradiated mice. We would examine the effects of these radioprotectors on heavy ion-irradiated mice. In this fiscal year, we actually found that vanadate protects mice that were total body irradiated with carbon ion beams. The radioprotective effect of 5CHQ on heavy ion-irradiated mice is currently under investigation. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成29 年度HIMAC 共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2018-04-17 | |||||
| 日付タイプ | Issued | |||||
